Version 5.4
Homo sapiens Gene: CPA4
Summary
InnateDB Gene IDBG-41240.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CPA4
Gene Name carboxypeptidase A4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000128510
Encoded Proteins
IDBP-41242
carboxypeptidase A4
IDBP-361812
carboxypeptidase A4
IDBP-478244
carboxypeptidase A4
IDBP-482164
carboxypeptidase A4
IDBP-482703
carboxypeptidase A4
IDBP-475493
carboxypeptidase A4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the carboxypeptidase A/B subfamily, and it is located in a cluster with three other family members on chromosome 7. Carboxypeptidases are zinc-containing exopeptidases that catalyze the release of carboxy-terminal amino acids, and are synthesized as zymogens that are activated by proteolytic cleavage. This gene could be involved in the histone hyperacetylation pathway. It is imprinted and may be a strong candidate gene for prostate cancer aggressiveness. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:130293134-130324180
Strand Forward strand
Band q32.2
Transcripts
ENST00000222482 ENSP00000222482
ENST00000445470 ENSP00000412947
ENST00000497388
ENST00000470542
ENST00000474254
ENST00000492072 ENSP00000417255
ENST00000490117
ENST00000473956 ENSP00000418392
ENST00000493259 ENSP00000419660
ENST00000486598 ENSP00000418276
ENST00000488025
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004180 carboxypeptidase activity
GO:0004181 metallocarboxypeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
GO:0016573 histone acetylation
Cellular Component
GO:0005575 cellular_component
GO:0005576 extracellular region
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000039070
View Gene Order
ENSBTAG00000046648
Not yet available
Cross-References
SwissProt
TrEMBL C9J7D6
UniProt Splice Variant
Entrez Gene 51200
UniGene Hs.616677 Hs.93764
RefSeq NM_001163446 NM_016352
HUGO HGNC:15740
OMIM 607635
CCDS CCDS55163 CCDS5818
HPRD 07405
IMGT
EMBL AC024085
GenPept
RNA Seq Atlas 51200

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca