Version 5.4
Homo sapiens Protein: CPA4
Summary
InnateDB Protein IDBP-361812.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CPA4
Protein Name carboxypeptidase A4
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000412947
InnateDB Gene IDBG-41240 (CPA4)
Protein Structure
UniProt Annotation
Function Metalloprotease that could be involved in the histone hyperacetylation pathway. {ECO:0000269PubMed:10383164}.
Subcellular Localization Secreted {ECO:0000250}.
Disease Associations
Tissue Specificity Fetal expression in the adrenal gland, brain, heart, intestine, kidney, liver and lung. Except for fetal brain that shows no imprinting, expression was found preferentially from the maternal allele.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004180 carboxypeptidase activity
GO:0004181 metallocarboxypeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
GO:0016573 histone acetylation
Cellular Component
GO:0005575 cellular_component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID
InterPro IPR000834 Peptidase M14, carboxypeptidase A
IPR003146 Proteinase inhibitor, carboxypeptidase propeptide
IPR009020 Proteinase inhibitor, propeptide
PFAM PF00246
PF02244
PRINTS PR00765
PIRSF
SMART SM00631
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UI42
PhosphoSite PhosphoSite-Q9UI42
TrEMBL C9J6N7
UniProt Splice Variant
Entrez Gene 51200
UniGene Hs.93764
RefSeq NP_001156918
HUGO HGNC:15740
OMIM 607635
CCDS CCDS55163
HPRD 07405
IMGT
EMBL AC024085 AF095719 AK298550 AY358699 BC052289
GenPept AAF23230 AAH52289 AAQ89062 BAH12812

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca