InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NLGN4X

Summary

InnateDB Gene

IDBG-41664.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NLGN4X

Gene Name

neuroligin 4, X-linked

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000146938

Encoded Proteins

IDBP-41666

neuroligin 4, X-linked

IDBP-41668

neuroligin 4, X-linked

IDBP-41670

neuroligin 4, X-linked

IDBP-41672

neuroligin 4, X-linked

IDBP-588924

neuroligin 4, X-linked

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. The encoded protein interacts with discs, large (Drosophila) homolog 4 (DLG4). Mutations in this gene have been associated with autism and Asperger syndrome. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:5840637-6228863

Strand

Reverse strand

Band

p22.31

Transcripts

ENST00000381095	ENSP00000370485
ENST00000275857	ENSP00000275857
ENST00000381093	ENSP00000370483
ENST00000381092	ENSP00000370482
ENST00000477079
ENST00000469740
ENST00000483337
ENST00000538097	ENSP00000439203

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0016787	hydrolase activity
GO:0031404	chloride ion binding
GO:0042043	neurexin family protein binding
GO:0042803	protein homodimerization activity
GO:0050839	cell adhesion molecule binding

Biological Process

GO:0003360	brainstem development
GO:0007158	neuron cell-cell adhesion
GO:0007612	learning
GO:0008152	metabolic process
GO:0021549	cerebellum development
GO:0030182	neuron differentiation
GO:0030534	adult behavior
GO:0035176	social behavior
GO:0035265	organ growth
GO:0045216	cell-cell junction organization
GO:0050808	synapse organization
GO:0071625	vocalization behavior
GO:0090394	negative regulation of excitatory postsynaptic membrane potential
GO:0097105	presynaptic membrane assembly

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009986	cell surface
GO:0014069	postsynaptic density
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0030425	dendrite
GO:0045202	synapse
GO:0045211	postsynaptic membrane
GO:0060076	excitatory synapse

Orthologs

No orthologs found for this gene

Pathways

NETPATH

REACTOME

KEGG

hsa04514

Cell adhesion molecules (CAMs) pathway

INOH

PID NCI

Cross-References

SwissProt

Q8N0W4

TrEMBL

A0A024RBV0 B3KMT6

UniProt Splice Variant

Entrez Gene

57502

UniGene

Hs.21107

RefSeq

NM_001282145 NM_001282146 NM_020742 NM_181332

HUGO

HGNC:14287

OMIM

300427

CCDS

CCDS14126

HPRD

IMGT

EMBL

AB033086 AF376803 AK022621 AY358562 BC034018 CH471074

GenPept

AAH34018 AAM46112 AAQ88925 BAA86574 BAG51098 EAW98738 EAW98739 EAW98741

RNA Seq Atlas

57502