Version 5.4
Homo sapiens Gene: MND1
Summary
InnateDB Gene IDBG-41682.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MND1
Gene Name meiotic nuclear divisions 1 homolog (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000121211
Encoded Proteins
IDBP-41684
meiotic nuclear divisions 1 homolog (S. cerevisiae)
IDBP-476547
meiotic nuclear divisions 1 homolog (S. cerevisiae)
IDBP-484640
meiotic nuclear divisions 1 homolog (S. cerevisiae)
IDBP-475544
meiotic nuclear divisions 1 homolog (S. cerevisiae)
IDBP-807145
meiotic nuclear divisions 1 homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The product of the MND1 gene associates with HOP2 (MIM 608665) to form a stable heterodimeric complex that binds DNA and stimulates the recombinase activity of RAD51 (MIM 179617) and DMC1 (MIM 602721) (Chi et al., 2007 [PubMed 17639080]). Both the MND1 and HOP2 genes are indispensable for meiotic recombination.[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:153344649-153415118
Strand Forward strand
Band q31.3
Transcripts
ENST00000240488 ENSP00000240488
ENST00000503967
ENST00000509752 ENSP00000427559
ENST00000508731 ENSP00000425500
ENST00000504860 ENSP00000422933
ENST00000622785 ENSP00000477758
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
Biological Process
GO:0006310 DNA recombination
GO:0007126 meiotic nuclear division
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000033752
View Gene Order
ENSBTAG00000000281
Not yet available
Pathways
NETPATH
REACTOME
REACT_27271
Meiotic recombination pathway
REACT_115566
Cell Cycle pathway
REACT_111183
Meiosis pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.294088
RefSeq NM_001253861 NM_032117 XM_006714340
HUGO
OMIM
CCDS CCDS3782 CCDS75202
HPRD 17025
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca