Version 5.4
Homo sapiens Protein: MND1
Summary
InnateDB Protein IDBP-41684.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MND1
Protein Name meiotic nuclear divisions 1 homolog (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000240488
InnateDB Gene IDBG-41682 (MND1)
Protein Structure
UniProt Annotation
Function Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis (By similarity). Stimulates both DMC1- and RAD51-mediated homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks. {ECO:0000250UniProtKB:Q8K396, ECO:0000269PubMed:16407260}.
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
Biological Process
GO:0006310 DNA recombination
GO:0007126 meiotic nuclear division
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR005647 Meiotic nuclear division protein 1
IPR005650 BlaI transcriptional regulatory family
PFAM PF03962
PF03965
PRINTS
PIRSF PIRSF026991
PIRSF019455
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BWT6
PhosphoSite PhosphoSite-Q9BWT6
TrEMBL D6RCT6
UniProt Splice Variant
Entrez Gene 84057
UniGene Hs.294088
RefSeq NP_115493
HUGO HGNC:24839
OMIM 611422
CCDS CCDS3782
HPRD 17025
IMGT
EMBL AC013477 AK312172 AY028916 BC032142 CH471056
GenPept AAH32142 AAK26168 BAG35106 EAX04964 EAX04965

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca