Version 5.4
Homo sapiens Gene: POP4
Summary
InnateDB Gene IDBG-41732.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol POP4
Gene Name processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae)
Synonyms RPP29
Species Homo sapiens
Ensembl Gene ENSG00000105171
Encoded Proteins
IDBP-41734
processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae)
IDBP-765281
IDBP-765353
IDBP-760260
IDBP-762218
IDBP-760873
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes one of the protein subunits of the small nucleolar ribonucleoprotein complexes: the endoribonuclease for mitochondrial RNA processing complex and the ribonuclease P complex. The encoded protein is localized to the nucleus and associates directly with the RNA component of these complexes. This protein is involved in processing of precursor RNAs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:29604017-29617237
Strand Forward strand
Band q12
Transcripts
ENST00000221770 ENSP00000221770
ENST00000585603 ENSP00000465213
ENST00000590688 ENSP00000467990
ENST00000591061 ENSP00000468718
ENST00000586136
ENST00000586420 ENSP00000468215
ENST00000586173
ENST00000586823 ENSP00000465456
ENST00000587232
ENST00000592759
ENST00000588551
ENST00000591824
ENST00000592749
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 2 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0004526 ribonuclease P activity
GO:0004540 ribonuclease activity
GO:0005515 protein binding
Biological Process
GO:0006364 rRNA processing
GO:0006379 mRNA cleavage
GO:0008033 tRNA processing
GO:0090501 RNA phosphodiester bond hydrolysis
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic
Cellular Component
GO:0000172 ribonuclease MRP complex
GO:0005655 nucleolar ribonuclease P complex
GO:0030677 ribonuclease P complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030423
View Gene Order
ENSBTAG00000002223
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa03013
RNA transport pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.412870 Hs.606430 Hs.715732
RefSeq NM_006627
HUGO
OMIM
CCDS CCDS12416
HPRD 09358
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca