Version 5.4
Homo sapiens Gene: PODXL
Summary
InnateDB Gene IDBG-41798.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PODXL
Gene Name podocalyxin-like
Synonyms Gp200; PC; PCLP; PCLP-1
Species Homo sapiens
Ensembl Gene ENSG00000128567
Encoded Proteins
IDBP-41800
podocalyxin-like
IDBP-41802
podocalyxin-like
IDBP-386378
podocalyxin-like
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the sialomucin protein family. The encoded protein was originally identified as an important component of glomerular podocytes. Podocytes are highly differentiated epithelial cells with interdigitating foot processes covering the outer aspect of the glomerular basement membrane. Other biological activities of the encoded protein include: binding in a membrane protein complex with Na+/H+ exchanger regulatory factor to intracellular cytoskeletal elements, playing a role in hematopoetic cell differentiation, and being expressed in vascular endothelium cells and binding to L-selectin. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:131500262-131558217
Strand Reverse strand
Band q32.3
Transcripts
ENST00000378555 ENSP00000367817
ENST00000322985 ENSP00000319782
ENST00000446198 ENSP00000390152
ENST00000484346
ENST00000490761
ENST00000487965
ENST00000482581
ENST00000465001
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 8 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007155 cell adhesion
GO:0007162 negative regulation of cell adhesion
GO:0016477 cell migration
GO:0022408 negative regulation of cell-cell adhesion
GO:0030335 positive regulation of cell migration
GO:0032534 regulation of microvillus assembly
GO:0033634 positive regulation of cell-cell adhesion mediated by integrin
GO:0050900 leukocyte migration
GO:0072015 glomerular visceral epithelial cell development
GO:0072175 epithelial tube formation
Cellular Component
GO:0001726 ruffle
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016324 apical plasma membrane
GO:0030027 lamellipodium
GO:0030175 filopodium
GO:0031528 microvillus membrane
GO:0036057 slit diaphragm
GO:0044297 cell body
GO:0045121 membrane raft
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025608
View Gene Order
ENSBTAG00000010452
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.743881
RefSeq NM_001018111 NM_005397
HUGO
OMIM
CCDS CCDS34755 CCDS47714
HPRD 04025
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca