Version 5.4
Homo sapiens Gene: PLRG1
Summary
InnateDB Gene IDBG-42004.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLRG1
Gene Name pleiotropic regulator 1
Synonyms Cwc1; PRL1; PRP46; PRPF46; TANGO4
Species Homo sapiens
Ensembl Gene ENSG00000171566
Encoded Proteins
IDBP-42006
pleiotropic regulator 1
IDBP-484102
pleiotropic regulator 1
IDBP-475296
pleiotropic regulator 1
IDBP-482377
pleiotropic regulator 1
IDBP-475564
pleiotropic regulator 1
IDBP-484564
pleiotropic regulator 1
IDBP-481007
pleiotropic regulator 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a core component of the cell division cycle 5-like (CDC5L) complex. The CDC5L complex is part of the spliceosome and is required for pre-mRNA splicing. The encoded protein plays a critical role in alternative splice site selection. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:154535006-154550435
Strand Reverse strand
Band q31.3
Transcripts
ENST00000302078 ENSP00000303191
ENST00000499023 ENSP00000424417
ENST00000512773
ENST00000506627 ENSP00000425914
ENST00000503251 ENSP00000426497
ENST00000507125
ENST00000506192 ENSP00000424616
ENST00000506918
ENST00000504341 ENSP00000423454
ENST00000512719
ENST00000509975 ENSP00000425147
ENST00000503751
ENST00000515520
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 53 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 53 [view]
Protein-Protein 53 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003714 transcription corepressor activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0007165 signal transduction
GO:0034504 protein localization to nucleus
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle
GO:2001141 regulation of RNA biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0016607 nuclear speck
GO:0071013 catalytic step 2 spliceosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027998
View Gene Order
ENSBTAG00000007234
Not yet available
Pathways
NETPATH
REACTOME
REACT_467
mRNA Splicing - Major Pathway pathway
REACT_125
Processing of Capped Intron-Containing Pre-mRNA pathway
REACT_1735
mRNA Splicing pathway
REACT_71
Gene Expression pathway
KEGG
hsa03040
Spliceosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.249996 Hs.593135 Hs.737778
RefSeq NM_001201564 NM_002669
HUGO
OMIM
CCDS CCDS34083 CCDS56341
HPRD 16181
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca