Version 5.4
Homo sapiens Protein: PLRG1
Summary
InnateDB Protein IDBP-42006.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLRG1
Protein Name pleiotropic regulator 1
Synonyms Cwc1; PRL1; PRP46; PRPF46; TANGO4;
Species Homo sapiens
Ensembl Protein ENSP00000303191
InnateDB Gene IDBG-42004 (PLRG1)
Protein Structure
UniProt Annotation
Function Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. {ECO:0000250}.
Subcellular Localization Nucleus. Nucleus speckle.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 53 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 53 [view]
Protein-Protein 53 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003714 transcription corepressor activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0007165 signal transduction
GO:2001141 regulation of RNA biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0016607 nuclear speck
GO:0071013 catalytic step 2 spliceosome
Protein Structure and Domains
PDB ID
InterPro IPR001680 WD40 repeat
IPR017986 WD40-repeat-containing domain
IPR020472 G-protein beta WD-40 repeat
PFAM PF00400
PRINTS PR00320
PIRSF
SMART SM00320
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O43660
PhosphoSite PhosphoSite-O43660
TrEMBL
UniProt Splice Variant
Entrez Gene 5356
UniGene Hs.737778
RefSeq NP_001188493
HUGO HGNC:9089
OMIM 605961
CCDS CCDS56341
HPRD 16181
IMGT
EMBL AF044333 AK002108 BC020786 BC106004 CH471056
GenPept AAD09407 AAH20786 AAI06005 BAG51016 EAX04941

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca