Version 5.4
Homo sapiens Gene: MLKL
Summary
InnateDB Gene IDBG-42130.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MLKL
Gene Name mixed lineage kinase domain-like
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000168404
Encoded Proteins
IDBP-42132
mixed lineage kinase domain-like
IDBP-42134
mixed lineage kinase domain-like
IDBP-750729
IDBP-750962
IDBP-746989
IDBP-750972
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 16:74671855-74700960
Strand Reverse strand
Band q23.1
Transcripts
ENST00000306247 ENSP00000303118
ENST00000308807 ENSP00000308351
ENST00000575695
ENST00000573267 ENSP00000459920
ENST00000576529 ENSP00000459935
ENST00000575686 ENSP00000461666
ENST00000570846
ENST00000571303 ENSP00000461110
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019901 protein kinase binding
GO:0032403 protein complex binding
Biological Process
GO:0006468 protein phosphorylation
GO:0070207 protein homotrimerization
GO:0070266 necroptotic process
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000012519
View Gene Order
ENSBTAG00000012216
Not yet available
Pathways
NETPATH
REACTOME
REACT_160189
Stimuli-sensing channels pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_25300
Ion channel transport pathway
REACT_169333
TRP channels pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL I3L2T9 I3L4Z5
UniProt Splice Variant
Entrez Gene 197259
UniGene Hs.119878
RefSeq NM_001142497 NM_152649 XM_005255834
HUGO HGNC:26617
OMIM 615153
CCDS CCDS32487 CCDS45528
HPRD 08752
IMGT
EMBL AC004685 AC109599
GenPept
RNA Seq Atlas 197259

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca