InnateDB Protein
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IDBP-42132.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MLKL
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Protein Name
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mixed lineage kinase domain-like
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000303118
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InnateDB Gene
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IDBG-42130 (MLKL)
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Protein Structure
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Function |
Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity. {ECO:0000269PubMed:22265413, ECO:0000269PubMed:22265414, ECO:0000269PubMed:22421439, ECO:0000269PubMed:24316671}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:24316671}. Cell membrane {ECO:0000269PubMed:24316671}. Note=Localizes to the cytoplasm and translocates to the plasma membrane on necroptosis induction.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
10
[view]
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Protein-Protein |
10
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR011009
Protein kinase-like domain
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8NB16
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PhosphoSite |
PhosphoSite-Q8NB16
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TrEMBL |
I3L4Z5
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UniProt Splice Variant |
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Entrez Gene |
197259
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UniGene |
Hs.119878
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RefSeq |
NP_001135969
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HUGO |
HGNC:26617
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OMIM |
615153
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CCDS |
CCDS45528
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HPRD |
08752
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IMGT |
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EMBL |
AC004685
AC109599
AK091708
BC028141
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GenPept |
AAH28141
BAC03728
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