Homo sapiens Gene: GUCY1A3 | |||||||||||||||||||||
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Summary | |||||||||||||||||||||
InnateDB Gene | IDBG-42375.6 | ||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||
Gene Symbol | GUCY1A3 | ||||||||||||||||||||
Gene Name | guanylate cyclase 1, soluble, alpha 3 | ||||||||||||||||||||
Synonyms | GC-SA3; GUC1A3; GUCA3; GUCSA3; GUCY1A1; MYMY6 | ||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||
Ensembl Gene | ENSG00000164116 | ||||||||||||||||||||
Encoded Proteins |
guanylate cyclase 1, soluble, alpha 3
guanylate cyclase 1, soluble, alpha 3
guanylate cyclase 1, soluble, alpha 3
guanylate cyclase 1, soluble, alpha 3
guanylate cyclase 1, soluble, alpha 3
guanylate cyclase 1, soluble, alpha 3
guanylate cyclase 1, soluble, alpha 3
guanylate cyclase 1, soluble, alpha 3
guanylate cyclase 1, soluble, alpha 3
guanylate cyclase 1, soluble, alpha 3
guanylate cyclase 1, soluble, alpha 3
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Protein Structure | |||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||
Summary |
Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3\',5\'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] |
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Gene Information | |||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||
Genomic Location | Chromosome 4:155666711-155732349 | ||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||
Band | q32.1 | ||||||||||||||||||||
Transcripts | |||||||||||||||||||||
Interactions | |||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||
NETPATH | |||||||||||||||||||||
REACTOME |
Nitric oxide stimulates guanylate cyclase pathway
Platelet homeostasis pathway
Hemostasis pathway
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KEGG |
Gap junction pathway
Purine metabolism pathway
Long-term depression pathway
Vascular smooth muscle contraction pathway
Salivary secretion pathway
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INOH |
Purine nucleotides nucleosides metabolism pathway
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PID NCI | |||||||||||||||||||||
Cross-References | |||||||||||||||||||||
SwissProt | Q02108 | ||||||||||||||||||||
TrEMBL | J3KPQ8 Q9NNW8 | ||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||
Entrez Gene | 2982 | ||||||||||||||||||||
UniGene | Hs.24258 Hs.623143 | ||||||||||||||||||||
RefSeq | NM_000856 NM_001130682 NM_001130683 NM_001130684 NM_001130685 NM_001130687 NM_001256449 XM_005262955 XM_005262956 XM_005262957 XM_006714196 XM_006714197 XM_006714198 | ||||||||||||||||||||
HUGO | HGNC:4685 | ||||||||||||||||||||
OMIM | 139396 | ||||||||||||||||||||
CCDS | CCDS34085 CCDS54812 | ||||||||||||||||||||
HPRD | 00768 | ||||||||||||||||||||
IMGT | |||||||||||||||||||||
EMBL | AC104083 AH009232 AK309950 BC028384 CH471056 U58855 X66534 Y15723 | ||||||||||||||||||||
GenPept | AAB94794 AAF64043 AAH28384 CAA47145 CAA75738 EAX04892 EAX04895 EAX04896 EAX04897 | ||||||||||||||||||||
RNA Seq Atlas | 2982 | ||||||||||||||||||||