InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: GUCY1A1

Summary

InnateDB Gene

IDBG-630672.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GUCY1A1

Gene Name

Guanylate cyclase soluble subunit alpha-1

Synonyms

GUCY1A1

Species

Bos taurus

Ensembl Gene

ENSBTAG00000014576

Encoded Proteins

IDBP-682146

Guanylate cyclase soluble subunit alpha-1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164116:
Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3\',5\'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:44600509-44665571

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000019398

ENSBTAP00000019398

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004383	guanylate cyclase activity
GO:0005525	GTP binding
GO:0016829	lyase activity
GO:0016849	phosphorus-oxygen lyase activity
GO:0020037	heme binding

Biological Process

GO:0006182	cGMP biosynthetic process
GO:0008217	regulation of blood pressure
GO:0009190	cyclic nucleotide biosynthetic process
GO:0030828	positive regulation of cGMP biosynthetic process
GO:0035556	intracellular signal transduction
GO:0052565	response to defense-related host nitric oxide production
GO:0060087	relaxation of vascular smooth muscle