Version 5.4
Homo sapiens Gene: LRP4
Summary
InnateDB Gene IDBG-42508.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LRP4
Gene Name low density lipoprotein receptor-related protein 4
Synonyms CLSS; LRP-4; LRP10; MEGF7; SOST2
Species Homo sapiens
Ensembl Gene ENSG00000134569
Encoded Proteins
IDBP-42512
low density lipoprotein receptor-related protein 4
IDBP-601755
low density lipoprotein receptor-related protein 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the low-density lipoprotein receptor-related protein family. The encoded protein may be a regulator of Wnt signaling. Mutations in this gene are associated with Cenani-Lenz syndrome. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:46856868-46918642
Strand Reverse strand
Band p11.2
Transcripts
ENST00000378623 ENSP00000367888
ENST00000529604
ENST00000527656
ENST00000529921
ENST00000534404 ENSP00000434763
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0030971 receptor tyrosine kinase binding
GO:0034185 apolipoprotein binding
GO:0042803 protein homodimerization activity
GO:0097110 scaffold protein binding
Biological Process
GO:0001822 kidney development
GO:0001932 regulation of protein phosphorylation
GO:0001942 hair follicle development
GO:0006897 endocytosis
GO:0008104 protein localization
GO:0009953 dorsal/ventral pattern formation
GO:0009954 proximal/distal pattern formation
GO:0016055 Wnt signaling pathway
GO:0030178 negative regulation of Wnt signaling pathway
GO:0030198 extracellular matrix organization
GO:0030279 negative regulation of ossification
GO:0030326 embryonic limb morphogenesis
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042733 embryonic digit morphogenesis
GO:0043113 receptor clustering
GO:0048813 dendrite morphogenesis
GO:0048856 anatomical structure development
GO:0050771 negative regulation of axonogenesis
GO:0050808 synapse organization
GO:0051124 synaptic growth at neuromuscular junction
GO:0051290 protein heterotetramerization
GO:0060173 limb development
GO:0071340 skeletal muscle acetylcholine-gated channel clustering
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0097104 postsynaptic membrane assembly
GO:0097105 presynaptic membrane assembly
GO:1901631 positive regulation of presynaptic membrane organization
Cellular Component
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0014069 postsynaptic density
GO:0016021 integral component of membrane
GO:0016600 flotillin complex
GO:0030425 dendrite
GO:0031594 neuromuscular junction
GO:0043025 neuronal cell body
GO:0097060 synaptic membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027253
View Gene Order
ENSBTAG00000008429
Not yet available
Pathways
NETPATH
REACTOME
REACT_118779
Extracellular matrix organization pathway
REACT_163906
ECM proteoglycans pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt O75096
TrEMBL
UniProt Splice Variant
Entrez Gene 4038
UniGene Hs.4930
RefSeq NM_002334 XM_005252923 XM_006718231
HUGO HGNC:6696
OMIM 604270
CCDS CCDS31478
HPRD 18517
IMGT
EMBL AB011540 AB084910 AB231861 AC021573 BC037360 BC041048 BC136667 BC136668
GenPept AAH37360 AAH41048 AAI36668 AAI36669 BAA32468 BAD83615 BAE19679
RNA Seq Atlas 4038

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca