Version 5.4
Homo sapiens Gene: GLI1
Summary
InnateDB Gene IDBG-42577.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GLI1
Gene Name GLI family zinc finger 1
Synonyms GLI
Species Homo sapiens
Ensembl Gene ENSG00000111087
Encoded Proteins
IDBP-42579
GLI family zinc finger 1
IDBP-600350
GLI family zinc finger 1
IDBP-601883
GLI family zinc finger 1
IDBP-588657
GLI family zinc finger 1
IDBP-586133
GLI family zinc finger 1
IDBP-586421
GLI family zinc finger 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 20547752
GLI1 functions as an antagonist of NF-kB activity after LPS stimulation at the level of promoter binding. GLI1 interacts with RELA (p65) upon LPS stimulation and inhibits RELA-mediated transcriptional transactivation by interfering with RELA binding to target gene promoter DNA.
Entrez Gene
Summary This gene encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:57460135-57472262
Strand Forward strand
Band q13.3
Transcripts
ENST00000228682 ENSP00000228682
ENST00000532291 ENSP00000436671
ENST00000528432 ENSP00000434421
ENST00000530789
ENST00000528467 ENSP00000434408
ENST00000527742
ENST00000546141 ENSP00000441006
ENST00000543426 ENSP00000437607
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 41 [view]
Protein-Protein 32 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 4 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0044212 transcription regulatory region DNA binding
GO:0046872 metal ion binding
Biological Process
GO:0001649 osteoblast differentiation
GO:0006366 transcription from RNA polymerase II promoter
GO:0007224 smoothened signaling pathway
GO:0007283 spermatogenesis
GO:0007418 ventral midline development
GO:0008284 positive regulation of cell proliferation
GO:0008589 regulation of smoothened signaling pathway
GO:0009913 epidermal cell differentiation
GO:0009953 dorsal/ventral pattern formation
GO:0009954 proximal/distal pattern formation
GO:0021696 cerebellar cortex morphogenesis
GO:0021938 smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation
GO:0021983 pituitary gland development
GO:0030324 lung development
GO:0045087 innate immune response (InnateDB)
GO:0045740 positive regulation of DNA replication
GO:0045880 positive regulation of smoothened signaling pathway
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048546 digestive tract morphogenesis
GO:0060032 notochord regression
GO:0090090 negative regulation of canonical Wnt signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005929 cilium
GO:0043231 intracellular membrane-bounded organelle
GO:0072372 primary cilium
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025407
View Gene Order
ENSBTAG00000006631
Not yet available
Pathways
NETPATH
NetPath_10
Hedgehog pathway
REACTOME
REACT_228134
Signaling by Hedgehog pathway
REACT_267605
Degradation of GLI1 by the proteasome pathway
REACT_111102
Signal Transduction pathway
REACT_267634
Hedgehog 'off' state pathway
KEGG
hsa04340
Hedgehog signaling pathway pathway
hsa05217
Basal cell carcinoma pathway
hsa05200
Pathways in cancer pathway
INOH
INOH website
Hedgehog signaling pathway pathway
PID NCI
hedgehog_glipathway
Hedgehog signaling events mediated by Gli proteins
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.632702
RefSeq NM_001160045 NM_001167609 NM_005269 XM_005268799
HUGO
OMIM
CCDS CCDS53806 CCDS53807 CCDS8940
HPRD 01311
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca