InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Gli1

Summary

InnateDB Gene

IDBG-195056.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gli1

Gene Name

GLI-Kruppel family member GLI1

Synonyms

AV235269; Zfp-5; Zfp5

Species

Mus musculus

Ensembl Gene

ENSMUSG00000025407

Encoded Proteins

IDBP-195058

GLI-Kruppel family member GLI1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 20547752

[Homo sapiens] GLI1 functions as an antagonist of NF-kB activity after LPS stimulation at the level of promoter binding. GLI1 interacts with RELA (p65) upon LPS stimulation and inhibits RELA-mediated transcriptional transactivation by interfering with RELA binding to target gene promoter DNA.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000111087:
This gene encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:127329889-127341589

Strand

Reverse strand

Band

Transcripts

ENSMUST00000026474

ENSMUSP00000026474

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0044212	transcription regulatory region DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0001649	osteoblast differentiation
GO:0006366	transcription from RNA polymerase II promoter
GO:0007165	signal transduction
GO:0007224	smoothened signaling pathway
GO:0007283	spermatogenesis
GO:0007418	ventral midline development
GO:0008284	positive regulation of cell proliferation
GO:0009913	epidermal cell differentiation
GO:0009953	dorsal/ventral pattern formation
GO:0009954	proximal/distal pattern formation
GO:0021696	cerebellar cortex morphogenesis
GO:0021938	smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation
GO:0021983	pituitary gland development
GO:0030324	lung development
GO:0045740	positive regulation of DNA replication
GO:0045880	positive regulation of smoothened signaling pathway
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060032	notochord regression
GO:0090090	negative regulation of canonical Wnt signaling pathway