Version 5.4
Homo sapiens Gene: GPR143
Summary
InnateDB Gene IDBG-42590.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GPR143
Gene Name G protein-coupled receptor 143
Synonyms NYS6; OA1
Species Homo sapiens
Ensembl Gene ENSG00000101850
Encoded Proteins
IDBP-361679
G protein-coupled receptor 143
IDBP-361681
G protein-coupled receptor 143
IDBP-484952
G protein-coupled receptor 143
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that binds to heterotrimeric G proteins and is targeted to melanosomes in pigment cells. This protein is thought to be involved in intracellular signal transduction mechanisms. Mutations in this gene cause ocular albinism type 1, also referred to as Nettleship-Falls type ocular albinism, a severe visual disorder. A related pseudogene has been identified on chromosome Y. [provided by RefSeq, Dec 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome X:9725346-9786297
Strand Reverse strand
Band p22.2
Transcripts
ENST00000447366 ENSP00000390546
ENST00000431126 ENSP00000406138
ENST00000467482 ENSP00000417161
ENST00000487206
ENST00000480178
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0005515 protein binding
GO:0035240 dopamine binding
GO:0035643 L-DOPA receptor activity
GO:0072544 L-DOPA binding
GO:0072545 tyrosine binding
Biological Process
GO:0006726 eye pigment biosynthetic process
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
GO:0007601 visual perception
GO:0032400 melanosome localization
GO:0032402 melanosome transport
GO:0032438 melanosome organization
GO:0035584 calcium-mediated signaling using intracellular calcium source
GO:0048015 phosphatidylinositol-mediated signaling
GO:0050848 regulation of calcium-mediated signaling
Cellular Component
GO:0005737 cytoplasm
GO:0005765 lysosomal membrane
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0033162 melanosome membrane
GO:0042470 melanosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025333
View Gene Order
ENSBTAG00000006472
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.684358 Hs.74124
RefSeq NM_000273 XM_005274541
HUGO
OMIM
CCDS CCDS14134
HPRD 02355
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca