Version 5.4
Bos taurus Gene: GPR143
Summary
InnateDB Gene IDBG-639469.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GPR143
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000006472
Encoded Proteins
IDBP-691637
G protein-coupled receptor 143
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000101850:
This gene encodes a protein that binds to heterotrimeric G proteins and is targeted to melanosomes in pigment cells. This protein is thought to be involved in intracellular signal transduction mechanisms. Mutations in this gene cause ocular albinism type 1, also referred to as Nettleship-Falls type ocular albinism, a severe visual disorder. A related pseudogene has been identified on chromosome Y. [provided by RefSeq, Dec 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome X:143861798-143891357
Strand Forward strand
Band
Transcripts
ENSBTAT00000008485 ENSBTAP00000008485
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0035240 dopamine binding
GO:0035643 L-DOPA receptor activity
GO:0072544 L-DOPA binding
GO:0072545 tyrosine binding
Biological Process
GO:0007218 neuropeptide signaling pathway
GO:0032400 melanosome localization
GO:0032402 melanosome transport
GO:0032438 melanosome organization
GO:0035584 calcium-mediated signaling using intracellular calcium source
GO:0048015 phosphatidylinositol-mediated signaling
GO:0050848 regulation of calcium-mediated signaling
Cellular Component
GO:0005765 lysosomal membrane
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0033162 melanosome membrane
GO:0042470 melanosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000101850
View Gene Order
ENSMUSG00000025333
View Gene Order
Cross-References
SwissProt
TrEMBL B6Z9Q6 B7TCH3 B7TCI3 G5E581
UniProt Splice Variant
Entrez Gene 613505
UniGene Bt.8695
RefSeq XM_002700459 XM_003584365 XM_864344
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02075555 FJ195365 FJ195366
GenPept ACJ15338 ACJ24806 ACJ24807 ACJ24809 ACJ24810 ACJ24811 ACJ61277 ACJ61278
RNA Seq Atlas 100849429 613505

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca