InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CEBPG

Summary

InnateDB Gene

IDBG-42640.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CEBPG

Gene Name

CCAAT/enhancer binding protein (C/EBP), gamma

Synonyms

GPE1BP; IG/EBP-1

Species

Homo sapiens

Ensembl Gene

ENSG00000153879

Encoded Proteins

IDBP-42642

CCAAT/enhancer binding protein (C/EBP), gamma

IDBP-760474

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The C/EBP family of transcription factors regulates viral and cellular CCAAT/enhancer element-mediated transcription. C/EBP proteins contain the bZIP region, which is characterized by two motifs in the C-terminal half of the protein: a basic region involved in DNA binding and a leucine zipper motif involved in dimerization. The C/EBP family consist of several related proteins, C/EBP alpha, C/EBP beta, C/EBP gamma, and C/EBP delta, that form homodimers and that form heterodimers with each other. CCAAT/enhancer binding protein gamma may cooperate with Fos to bind PRE-I enhancer elements. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:33373330-33382686

Strand

Forward strand

Band

q13.11

Transcripts

ENST00000284000	ENSP00000284000
ENST00000585933	ENSP00000466022

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	38 [view]
Protein-Protein	35 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0043565	sequence-specific DNA binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001889	liver development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006955	immune response
GO:0016071	mRNA metabolic process
GO:0030183	B cell differentiation
GO:0042267	natural killer cell mediated cytotoxicity
GO:0043353	enucleate erythrocyte differentiation
GO:0043388	positive regulation of DNA binding
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045078	positive regulation of interferon-gamma biosynthetic process
GO:0045739	positive regulation of DNA repair
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity

Cellular Component

GO:0005634

nucleus

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000056216

View Gene Order

ENSBTAG00000017560

Not yet available

Cross-References

SwissProt

P53567

TrEMBL

UniProt Splice Variant

Entrez Gene

1054

UniGene

Hs.429666 Hs.732150

RefSeq

NM_001252296 NM_001806

HUGO

HGNC:1837

OMIM

138972

CCDS

CCDS12432

HPRD

IMGT

EMBL

AK313634 BC007582 BC013128 BT019819 BT019820 U20240

GenPept

AAC50201 AAH07582 AAH13128 AAV38622 AAV38623 BAG36393

RNA Seq Atlas

1054