Version 5.4
Homo sapiens Gene: CLDN10
Summary
InnateDB Gene IDBG-42724.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLDN10
Gene Name claudin 10
Synonyms CPETRL3; OSP-L
Species Homo sapiens
Ensembl Gene ENSG00000134873
Encoded Proteins
IDBP-42726
claudin 10
IDBP-42728
claudin 10
IDBP-42730
claudin 10
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The expression level of this gene is associated with recurrence of primary hepatocellular carcinoma. Six alternatively spliced transcript variants encoding different isoforms have been reported, but the transcript sequences of some variants are not determined.[provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:95433604-95579759
Strand Forward strand
Band q32.1
Transcripts
ENST00000376873 ENSP00000366069
ENST00000299339 ENSP00000299339
ENST00000376855 ENSP00000366051
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0042802 identical protein binding
Biological Process
GO:0006811 ion transport
GO:0007155 cell adhesion
GO:0016338 calcium-independent cell-cell adhesion
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005923 tight junction
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022132
View Gene Order
ENSBTAG00000003568
Not yet available
Pathways
NETPATH
REACTOME
REACT_19373
Tight junction interactions pathway
REACT_111155
Cell-Cell communication pathway
REACT_20676
Cell junction organization pathway
REACT_19331
Cell-cell junction organization pathway
KEGG
hsa04514
Cell adhesion molecules (CAMs) pathway
hsa04670
Leukocyte transendothelial migration pathway
hsa04530
Tight junction pathway
hsa05160
Hepatitis C pathway
INOH
PID NCI
Cross-References
SwissProt P78369
TrEMBL Q5W075
UniProt Splice Variant
Entrez Gene 9071
UniGene Hs.534377
RefSeq NM_001160100 NM_006984 NM_182848
HUGO HGNC:2033
OMIM
CCDS CCDS9475 CCDS9476
HPRD
IMGT
EMBL AK055855 AK315737 AL139376 AL357061 AL627382 BC010920 CH471085 CR456845 U89916
GenPept AAC79506 AAH10920 BAB71030 BAG38092 CAG33126 CAH71596 CAI16403 EAX08955
RNA Seq Atlas 9071

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca