Version 5.4
Homo sapiens Protein: CLDN10
Summary
InnateDB Protein IDBP-42728.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLDN10
Protein Name claudin 10
Synonyms CPETRL3; OSP-L;
Species Homo sapiens
Ensembl Protein ENSP00000299339
InnateDB Gene IDBG-42724 (CLDN10)
Protein Structure
UniProt Annotation
Function Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. May form permselective paracellular pores; isoform 1 appears to create pores preferentially permeable to cations and isoform 2 for anions. Plays a key role in controlling cation selectivity and transport in the thick ascending limb (TAL) of Henle's loop in kidney. {ECO:0000269PubMed:19383724}.
Subcellular Localization Cell junction, tight junction {ECO:0000269PubMed:19383724}. Cell membrane {ECO:0000269PubMed:19383724}; Multi-pass membrane protein {ECO:0000269PubMed:19383724}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0042802 identical protein binding
Biological Process
GO:0006811 ion transport
GO:0007155 cell adhesion
GO:0016338 calcium-independent cell-cell adhesion
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005923 tight junction
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR003554 Claudin-10
IPR004031 PMP-22/EMP/MP20/Claudin superfamily
IPR006187 Claudin
PFAM PF00822
PF13903
PRINTS PR01383
PR01077
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P78369
PhosphoSite PhosphoSite-P78369
TrEMBL Q5W075
UniProt Splice Variant
Entrez Gene 9071
UniGene Hs.534377
RefSeq NP_008915
HUGO HGNC:2033
OMIM
CCDS CCDS9476
HPRD 13063
IMGT
EMBL AK055855 AK315737 AL139376 AL357061 AL627382 BC010920 CH471085 CR456845 U89916
GenPept AAC79506 AAH10920 BAB71030 BAG38092 CAG33126 CAH71596 CAI16403 EAX08955

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca