Version 5.4
Homo sapiens Gene: DUSP18
Summary
InnateDB Gene IDBG-4294.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DUSP18
Gene Name dual specificity phosphatase 18
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000167065
Encoded Proteins
IDBP-4296
dual specificity phosphatase 18
IDBP-55648
dual specificity phosphatase 18
IDBP-60611
dual specificity phosphatase 18
IDBP-294458
dual specificity phosphatase 18
IDBP-294454
dual specificity phosphatase 18
IDBP-293298
dual specificity phosphatase 18
IDBP-372162
dual specificity phosphatase 18
IDBP-372167
dual specificity phosphatase 18
IDBP-372178
dual specificity phosphatase 18
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP18 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:30652051-30667890
Strand Reverse strand
Band q12.2
Transcripts
ENST00000334679 ENSP00000333917
ENST00000342474 ENSP00000340795
ENST00000377087 ENSP00000366291
ENST00000404885 ENSP00000385463
ENST00000407308 ENSP00000386063
ENST00000403268 ENSP00000384946
ENST00000430175 ENSP00000414825
ENST00000412865 ENSP00000387680
ENST00000442752 ENSP00000403378
ENST00000461301
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004725 protein tyrosine phosphatase activity
GO:0008138 protein tyrosine/serine/threonine phosphatase activity
GO:0016791 phosphatase activity
GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity
Biological Process
GO:0000188 inactivation of MAPK activity
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation
GO:0035335 peptidyl-tyrosine dephosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000047205
View Gene Order
ENSBTAG00000017459
Not yet available
Cross-References
SwissProt
TrEMBL F8VX42
UniProt Splice Variant
Entrez Gene 150290
UniGene Hs.517544 Hs.680453
RefSeq NM_152511 XM_005261367
HUGO HGNC:18484
OMIM 611446
CCDS CCDS13883
HPRD 13253
IMGT
EMBL AC003072 AC005006
GenPept
RNA Seq Atlas 150290

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca