Version 5.4
Homo sapiens Protein: DUSP18
Summary
InnateDB Protein IDBP-294454.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DUSP18
Protein Name dual specificity phosphatase 18
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000386063
InnateDB Gene IDBG-4294 (DUSP18)
Protein Structure
UniProt Annotation
Function Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine. In vitro, dephosphorylates p-nitrophenyl phosphate (pNPP).
Subcellular Localization Cytoplasm {ECO:0000269PubMed:12408986}. Nucleus {ECO:0000269PubMed:12408986}.
Disease Associations
Tissue Specificity Widely expressed with highest levels in liver, brain, ovary and testis. {ECO:0000269PubMed:12408986, ECO:0000269PubMed:12591617}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004725 protein tyrosine phosphatase activity
GO:0008138 protein tyrosine/serine/threonine phosphatase activity
GO:0016791 phosphatase activity
GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity
Biological Process
GO:0000188 inactivation of MAPK activity
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation
GO:0035335 peptidyl-tyrosine dephosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000340 Dual specificity phosphatase, catalytic domain
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR020417 Atypical dual specificity phosphatase
IPR020420 Atypical dual specificity phosphatase, subfamily B
IPR020422 Dual specificity phosphatase, subgroup, catalytic domain
IPR029021 Protein-tyrosine phosphatase-like
PFAM PF00782
PRINTS PR01908
PR01910
PIRSF
SMART SM00195
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8NEJ0
PhosphoSite PhosphoSite-
TrEMBL F8VX42
UniProt Splice Variant
Entrez Gene 150290
UniGene Hs.680453
RefSeq XP_005261423
HUGO HGNC:18484
OMIM 611446
CCDS CCDS13883
HPRD 13253
IMGT
EMBL AC003072 AC005006 AF461689 AF533017 AK056074 BC030987 CH471095 CR456406
GenPept AAH30987 AAN59787 AAN77931 BAG51616 CAG30292 EAW59913 EAW59914 EAW59915

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca