InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: UBA2

Summary

InnateDB Gene

IDBG-42984.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UBA2

Gene Name

ubiquitin-like modifier activating enzyme 2

Synonyms

ARX; SAE2

Species

Homo sapiens

Ensembl Gene

ENSG00000126261

Encoded Proteins

IDBP-42986

ubiquitin-like modifier activating enzyme 2

IDBP-603524

ubiquitin-like modifier activating enzyme 2

IDBP-761701

IDBP-763943

IDBP-809301

ubiquitin-like modifier activating enzyme 2

IDBP-760795

IDBP-809263

ubiquitin-like modifier activating enzyme 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 (MIM 613294) and UBA2 form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).[supplied by OMIM, Mar 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:34428352-34471251

Strand

Forward strand

Band

q13.11

Transcripts

ENST00000246548	ENSP00000246548
ENST00000439527	ENSP00000437484
ENST00000591016	ENSP00000468756
ENST00000592672
ENST00000588585
ENST00000590048	ENSP00000467433
ENST00000592791	ENSP00000475656
ENST00000592841
ENST00000586313	ENSP00000468538
ENST00000607361	ENSP00000475565

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 78 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	78 [view]
Protein-Protein	77 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008047	enzyme activator activity
GO:0008134	transcription factor binding
GO:0008641	small protein activating enzyme activity
GO:0016874	ligase activity
GO:0019948	SUMO activating enzyme activity
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006464	cellular protein modification process
GO:0008152	metabolic process
GO:0016925	protein sumoylation
GO:0019950	SMT3-dependent protein catabolic process
GO:0043085	positive regulation of catalytic activity
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0005654	nucleoplasm
GO:0005829	cytosol
GO:0031510	SUMO activating enzyme complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000052997

View Gene Order

ENSBTAG00000002573

Not yet available

Pathways

NETPATH

REACTOME

REACT_22161

Post-translational protein modification pathway

REACT_163793

Processing and activation of SUMO pathway

REACT_17015

Metabolism of proteins pathway

REACT_163646

SUMO is transferred from E1 to E2 (UBE2I, UBC9) pathway

REACT_163812

SUMO is conjugated to E1 (UBA2:SAE1) pathway

REACT_163823

SUMOylation pathway

KEGG

hsa04120

Ubiquitin mediated proteolysis pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

U3KQ55

UniProt Splice Variant

Entrez Gene

10054

UniGene

RefSeq

NM_005499 XM_005258404 XM_006722962

HUGO

HGNC:30661

OMIM

613295

CCDS

CCDS12439

HPRD

IMGT

EMBL

AC008747

GenPept

RNA Seq Atlas

10054