InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UBA2

Summary

InnateDB Protein

IDBP-42986.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UBA2

Protein Name

ubiquitin-like modifier activating enzyme 2

Synonyms

ARX; SAE2;

Species

Homo sapiens

Ensembl Protein

ENSP00000246548

InnateDB Gene

IDBG-42984 (UBA2)

Protein Structure

UniProt Annotation

Function

The heterodimer acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. {ECO:0000269PubMed:11451954, ECO:0000269PubMed:11481243, ECO:0000269PubMed:15660128, ECO:0000269PubMed:17643372, ECO:0000269PubMed:19443651, ECO:0000269PubMed:20164921}.

Subcellular Localization

Cytoplasm. Nucleus. Note=Shuttles between the cytoplasm and the nucleus, sumoylation is required either for nuclear translocation or nuclear retention.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 78 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	78 [view]
Protein-Protein	77 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008047	enzyme activator activity
GO:0008134	transcription factor binding
GO:0008641	small protein activating enzyme activity
GO:0016874	ligase activity
GO:0019948	SUMO activating enzyme activity
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006464	cellular protein modification process
GO:0016925	protein sumoylation
GO:0019950	SMT3-dependent protein catabolic process
GO:0043085	positive regulation of catalytic activity
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0005654	nucleoplasm
GO:0005829	cytosol
GO:0031510	SUMO activating enzyme complex

Protein Structure and Domains

PDB ID

InterPro

IPR000127 Ubiquitin-activating enzyme repeat
IPR000594 UBA/THIF-type NAD/FAD binding fold
IPR009036 Molybdenum cofactor biosynthesis, MoeB
IPR019572 Ubiquitin-activating enzyme

PFAM

PF02134
PF00899
PF10585

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9UBT2

PhosphoSite