Version 5.4
Homo sapiens Gene: PPID
Summary
InnateDB Gene IDBG-43002.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPID
Gene Name peptidylprolyl isomerase D
Synonyms CYP-40; CYPD
Species Homo sapiens
Ensembl Gene ENSG00000171497
Encoded Proteins
IDBP-43004
peptidylprolyl isomerase D
IDBP-475664
peptidylprolyl isomerase D
IDBP-477398
peptidylprolyl isomerase D
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein has been shown to possess PPIase activity and, similar to other family members, can bind to the immunosuppressant cyclosporin A. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:158709134-158723396
Strand Reverse strand
Band q32.1
Transcripts
ENST00000307720 ENSP00000303754
ENST00000512699 ENSP00000423207
ENST00000507213 ENSP00000421221
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 58 experimentally validated interaction(s) in this database.
Experimentally validated
Total 58 [view]
Protein-Protein 58 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003755 peptidyl-prolyl cis-trans isomerase activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0016018 cyclosporin A binding
GO:0030331 estrogen receptor binding
GO:0030544 Hsp70 protein binding
GO:0031072 heat shock protein binding
GO:0051879 Hsp90 protein binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000413 protein peptidyl-prolyl isomerization
GO:0006457 protein folding
GO:0006461 protein complex assembly
GO:0006915 apoptotic process
GO:0015031 protein transport
GO:0019076 viral release from host cell
GO:0034389 lipid particle organization
GO:0043065 positive regulation of apoptotic process
GO:0045070 positive regulation of viral genome replication
GO:0050714 positive regulation of protein secretion
GO:0061077 chaperone-mediated protein folding
GO:0071492 cellular response to UV-A
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027804
View Gene Order
ENSBTAG00000016680
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
cmyb_pathway
C-MYB transcription factor network
Cross-References
SwissProt
TrEMBL H0Y8J0
UniProt Splice Variant
Entrez Gene 5481
UniGene Hs.183958
RefSeq NM_005038
HUGO HGNC:9257
OMIM 601753
CCDS CCDS3801
HPRD 11875
IMGT
EMBL AC107219
GenPept
RNA Seq Atlas 5481

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca