InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PPID

Summary

InnateDB Protein

IDBP-43004.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPID

Protein Name

peptidylprolyl isomerase D

Synonyms

CYP-40; CYPD;

Species

Homo sapiens

Ensembl Protein

ENSP00000303754

InnateDB Gene

IDBG-43002 (PPID)

Protein Structure

UniProt Annotation

Function

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroid receptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thus establishing distinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity control. May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor complexes. May be involved in cytoplasmic dynein-dependent movement of the receptor from the cytoplasm to the nucleus. May regulate MYB by inhibiting its DNA- binding activity. Involved in regulation of AHR signaling by promoting the formation of the AHR:ARNT dimer; the function is independent of HSP90 but requires the chaperone activity. Involved in regulation of UV radiation-induced apoptosis. Promotes cell viability in anaplastic lymphoma kinase-positive anaplastic large- cell lymphoma (ALK+ ALCL) cell lines. May be involved in hepatitis C virus (HCV) replication and release. {ECO:0000269PubMed:11350175, ECO:0000269PubMed:18708059, ECO:0000269PubMed:19932913, ECO:0000269PubMed:21711559, ECO:0000269PubMed:22681779, ECO:0000269PubMed:23220213, ECO:0000269PubMed:9659917}.

Subcellular Localization

Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm.

Disease Associations

Tissue Specificity

Widely expressed.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 58 experimentally validated interaction(s) in this database.

Experimentally validated
Total	58 [view]
Protein-Protein	58 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003755	peptidyl-prolyl cis-trans isomerase activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0016018	cyclosporin A binding
GO:0030331	estrogen receptor binding
GO:0030544	Hsp70 protein binding
GO:0031072	heat shock protein binding
GO:0051879	Hsp90 protein binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000413	protein peptidyl-prolyl isomerization
GO:0006457	protein folding
GO:0006461	protein complex assembly
GO:0006915	apoptotic process
GO:0015031	protein transport
GO:0019076	viral release from host cell
GO:0034389	lipid particle organization
GO:0043065	positive regulation of apoptotic process
GO:0045070	positive regulation of viral genome replication
GO:0050714	positive regulation of protein secretion
GO:0061077	chaperone-mediated protein folding
GO:0071492	cellular response to UV-A

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR001440 Tetratricopeptide TPR1
IPR002130 Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain
IPR013026 Tetratricopeptide repeat-containing domain
IPR019734 Tetratricopeptide repeat
IPR029000 Cyclophilin-like domain

PFAM

PF00515
PF00160
PF13174
PF13176
PF13181

PRINTS

PR00153

PIRSF

SMART

SM00028

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt