Version 5.4
Homo sapiens Gene: DTX3
Summary
InnateDB Gene IDBG-43027.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DTX3
Gene Name deltex homolog 3 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000178498
Encoded Proteins
IDBP-43029
deltex homolog 3 (Drosophila)
IDBP-595350
deltex homolog 3 (Drosophila)
IDBP-586083
deltex homolog 3 (Drosophila)
IDBP-583122
deltex homolog 3 (Drosophila)
IDBP-602534
deltex homolog 3 (Drosophila)
IDBP-594010
deltex homolog 3 (Drosophila)
IDBP-597837
deltex homolog 3 (Drosophila)
IDBP-590973
deltex homolog 3 (Drosophila)
IDBP-587230
deltex homolog 3 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary DTX3 functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).[supplied by OMIM, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:57604622-57609804
Strand Forward strand
Band q13.3
Transcripts
ENST00000337737 ENSP00000338050
ENST00000548804 ENSP00000449294
ENST00000550596 ENSP00000449118
ENST00000551835 ENSP00000449950
ENST00000549583 ENSP00000449688
ENST00000548198 ENSP00000447873
ENST00000551632 ENSP00000448696
ENST00000548478 ENSP00000448224
ENST00000550300 ENSP00000446996
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 24 [view]
Protein-Protein 24 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0007219 Notch signaling pathway
GO:0016567 protein ubiquitination
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000040415
View Gene Order
ENSBTAG00000018002
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04330
Notch signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt Q8N9I9
TrEMBL F8VUZ4
UniProt Splice Variant
Entrez Gene 196403
UniGene Hs.32374
RefSeq NM_001286245 XM_005268697 XM_005268698 XM_005268700 NM_001286246 NM_178502
HUGO HGNC:24457
OMIM 613142
CCDS CCDS66410 CCDS41800
HPRD 16842
IMGT
EMBL AC022506 AC025165 AK092085 AK094385 AK128752 AL831941 AY225126 BC114441 BC114498 CH471054
GenPept AAI14442 AAI14499 AAP57520 BAC03801 BAC04344 BAG54727 CAD38593 EAW97033
RNA Seq Atlas 196403

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca