Version 5.4
Homo sapiens Gene: PRICKLE2
Summary
InnateDB Gene IDBG-43075.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRICKLE2
Gene Name prickle homolog 2 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000163637
Encoded Proteins
IDBP-43077
prickle homolog 2 (Drosophila)
IDBP-484917
prickle homolog 2 (Drosophila)
IDBP-719639
IDBP-719658
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a homolog of Drosophila prickle. The exact function of this gene is not known, however, studies in mice suggest that it may be involved in seizure prevention. Mutations in this gene are associated with progressive myoclonic epilepsy type 5. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:64093867-64445476
Strand Reverse strand
Band p14.1
Transcripts
ENST00000295902 ENSP00000295902
ENST00000498162 ENSP00000419951
ENST00000564377 ENSP00000455004
ENST00000569824 ENSP00000456173
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
GO:0031175 neuron projection development
GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity
Cellular Component
GO:0005737 cytoplasm
GO:0016327 apicolateral plasma membrane
GO:0016328 lateral plasma membrane
GO:0031965 nuclear membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030020
View Gene Order
ENSBTAG00000021835
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04310
Wnt signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL H3BRB9
UniProt Splice Variant
Entrez Gene 166336
UniGene Hs.581368 Hs.743295
RefSeq NM_198859 XM_005264910 XM_005264911 XM_006713006 XM_006713007
HUGO HGNC:20340
OMIM 608501
CCDS CCDS2902
HPRD 16342
IMGT
EMBL AC092040 AC096888 AC103557 AC136275
GenPept
RNA Seq Atlas 166336

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca