Version 5.4
Mus musculus Gene: Prickle2
Summary
InnateDB Gene IDBG-171127.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Prickle2
Gene Name prickle homolog 2 (Drosophila)
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000030020
Encoded Proteins
IDBP-171129
prickle homolog 2 (Drosophila)
IDBP-253861
prickle homolog 2 (Drosophila)
IDBP-253863
prickle homolog 2 (Drosophila)
IDBP-253865
prickle homolog 2 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163637:
This gene encodes a homolog of Drosophila prickle. The exact function of this gene is not known, however, studies in mice suggest that it may be involved in seizure prevention. Mutations in this gene are associated with progressive myoclonic epilepsy type 5. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:92370892-92706145
Strand Reverse strand
Band D1
Transcripts
ENSMUST00000032093 ENSMUSP00000032093
ENSMUST00000113447 ENSMUSP00000109074
ENSMUST00000113446 ENSMUSP00000109073
ENSMUST00000113445 ENSMUSP00000109072
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
GO:0031175 neuron projection development
GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity
Cellular Component
GO:0005737 cytoplasm
GO:0016327 apicolateral plasma membrane
GO:0016328 lateral plasma membrane
GO:0031965 nuclear membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000163637
View Gene Order
ENSBTAG00000021835
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04310
Wnt signaling pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04310
Wnt signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt Q80Y24
TrEMBL
UniProt Splice Variant
Entrez Gene 243548
UniGene Mm.248820 Mm.405243
RefSeq NM_001134459 NM_001081146 NM_001134460 NM_001134461 XM_006506106 XM_006506107
OMIM
CCDS CCDS51854 CCDS39572
HPRD
IMGT
MGI ID MGI:1925144
MGI Symbol Prickle2
EMBL BC050793 BC145754 CH466523
GenPept AAH50793 AAI45755 EDK99322
RNA Seq Atlas 243548

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca