Version 5.4
Homo sapiens Gene: RAPGEF2
Summary
InnateDB Gene IDBG-43117.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RAPGEF2
Gene Name Rap guanine nucleotide exchange factor (GEF) 2
Synonyms CNrasGEF; nRap GEP; NRAPGEP; PDZ-GEF1; PDZGEF1; RA-GEF; RA-GEF-1; Rap-GEP
Species Homo sapiens
Ensembl Gene ENSG00000109756
Encoded Proteins
IDBP-43119
Rap guanine nucleotide exchange factor (GEF) 2
IDBP-478885
Rap guanine nucleotide exchange factor (GEF) 2
IDBP-475510
Rap guanine nucleotide exchange factor (GEF) 2
IDBP-474210
Rap guanine nucleotide exchange factor (GEF) 2
IDBP-473925
Rap guanine nucleotide exchange factor (GEF) 2
IDBP-480333
Rap guanine nucleotide exchange factor (GEF) 2
IDBP-475771
Rap guanine nucleotide exchange factor (GEF) 2
IDBP-475251
Rap guanine nucleotide exchange factor (GEF) 2
IDBP-483147
Rap guanine nucleotide exchange factor (GEF) 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF2, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:159104178-159360169
Strand Forward strand
Band q32.1
Transcripts
ENST00000264431 ENSP00000264431
ENST00000505478 ENSP00000422707
ENST00000504604
ENST00000503328
ENST00000511336 ENSP00000421602
ENST00000510510 ENSP00000421740
ENST00000514565 ENSP00000422361
ENST00000513816
ENST00000512056 ENSP00000421624
ENST00000502485 ENSP00000422098
ENST00000510253 ENSP00000421083
ENST00000505026 ENSP00000427334
ENST00000509891
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 25 [view]
Protein-Protein 25 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0017034 Rap guanyl-nucleotide exchange factor activity
GO:0019901 protein kinase binding
GO:0019992 diacylglycerol binding
GO:0030165 PDZ domain binding
GO:0030552 cAMP binding
GO:0031697 beta-1 adrenergic receptor binding
GO:0046582 Rap GTPase activator activity
GO:0050699 WW domain binding
Biological Process
GO:0000165 MAPK cascade
GO:0001568 blood vessel development
GO:0001764 neuron migration
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
GO:0007264 small GTPase mediated signal transduction
GO:0008285 negative regulation of cell proliferation
GO:0010976 positive regulation of neuron projection development
GO:0019933 cAMP-mediated signaling
GO:0021591 ventricular system development
GO:0021884 forebrain neuron development
GO:0031175 neuron projection development
GO:0031547 brain-derived neurotrophic factor receptor signaling pathway
GO:0032092 positive regulation of protein binding
GO:0032320 positive regulation of Ras GTPase activity
GO:0032486 Rap protein signal transduction
GO:0032854 positive regulation of Rap GTPase activity
GO:0035556 intracellular signal transduction
GO:0038180 nerve growth factor signaling pathway
GO:0043950 positive regulation of cAMP-mediated signaling
GO:0045860 positive regulation of protein kinase activity
GO:0048022 negative regulation of melanin biosynthetic process
GO:0048167 regulation of synaptic plasticity
GO:0050774 negative regulation of dendrite morphogenesis
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0061028 establishment of endothelial barrier
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071320 cellular response to cAMP
GO:0071321 cellular response to cGMP
GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway
GO:1901888 regulation of cell junction assembly
GO:1990090 cellular response to nerve growth factor stimulus
GO:2000481 positive regulation of cAMP-dependent protein kinase activity
GO:2000670 positive regulation of dendritic cell apoptotic process
GO:2001214 positive regulation of vasculogenesis
GO:2001224 positive regulation of neuron migration
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005770 late endosome
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005911 cell-cell junction
GO:0016020 membrane
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043234 protein complex
GO:0045202 synapse
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000062232
View Gene Order
ENSBTAG00000012450
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04010
MAPK signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.113912 Hs.717779 Hs.731539
RefSeq NM_014247 XM_005263360 XM_005263361
HUGO
OMIM
CCDS CCDS43277
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca