Version 5.4
Mus musculus Gene: Rapgef2
Summary
InnateDB Gene IDBG-152904.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rapgef2
Gene Name Rap guanine nucleotide exchange factor (GEF) 2
Synonyms 5830453M24Rik; CNRasGEF; mKIAA0313; nRapGEP; Pdzgef1; RA-GEF-1
Species Mus musculus
Ensembl Gene ENSMUSG00000062232
Encoded Proteins
IDBP-401303
Rap guanine nucleotide exchange factor (GEF) 2
IDBP-401305
Rap guanine nucleotide exchange factor (GEF) 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000109756:
Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF2, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:79062516-79181340
Strand Reverse strand
Band E3
Transcripts
ENSMUST00000118340 ENSMUSP00000113778
ENSMUST00000118100 ENSMUSP00000114119
ENSMUST00000152275
ENSMUST00000124647
ENSMUST00000136126
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005096 GTPase activator activity
GO:0005515 protein binding
GO:0017034 Rap guanyl-nucleotide exchange factor activity
GO:0019901 protein kinase binding
GO:0030165 PDZ domain binding
GO:0030552 cAMP binding
GO:0031697 beta-1 adrenergic receptor binding
GO:0046582 Rap GTPase activator activity
GO:0050699 WW domain binding
Biological Process
GO:0001568 blood vessel development
GO:0001764 neuron migration
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
GO:0007264 small GTPase mediated signal transduction
GO:0008285 negative regulation of cell proliferation
GO:0010976 positive regulation of neuron projection development
GO:0019933 cAMP-mediated signaling
GO:0021591 ventricular system development
GO:0021884 forebrain neuron development
GO:0031175 neuron projection development
GO:0031547 brain-derived neurotrophic factor receptor signaling pathway
GO:0032092 positive regulation of protein binding
GO:0032320 positive regulation of Ras GTPase activity
GO:0032486 Rap protein signal transduction
GO:0032854 positive regulation of Rap GTPase activity
GO:0038180 nerve growth factor signaling pathway
GO:0043950 positive regulation of cAMP-mediated signaling
GO:0045860 positive regulation of protein kinase activity
GO:0048022 negative regulation of melanin biosynthetic process
GO:0048167 regulation of synaptic plasticity
GO:0050774 negative regulation of dendrite morphogenesis
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0061028 establishment of endothelial barrier
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071320 cellular response to cAMP
GO:0071321 cellular response to cGMP
GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway
GO:1901888 regulation of cell junction assembly
GO:1990090 cellular response to nerve growth factor stimulus
GO:2000481 positive regulation of cAMP-dependent protein kinase activity
GO:2000670 positive regulation of dendritic cell apoptotic process
GO:2001214 positive regulation of vasculogenesis
GO:2001224 positive regulation of neuron migration
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005770 late endosome
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0016020 membrane
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043234 protein complex
GO:0045202 synapse
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000109756
View Gene Order
ENSBTAG00000012450
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04010
MAPK signaling pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04010
MAPK signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E9QNQ4
UniProt Splice Variant
Entrez Gene 76089
UniGene Mm.31220 Mm.415684 Mm.462396
RefSeq NM_001099624 XM_006502250 XM_006502251 XM_006502252 XM_006502254 XM_006502255
OMIM
CCDS CCDS50932
HPRD
IMGT
MGI ID MGI:2659071
MGI Symbol Rapgef2
EMBL AC124358 AC157941 AC164560
GenPept
RNA Seq Atlas 76089

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca