InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MAF

Summary

InnateDB Gene

IDBG-43180.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAF

Gene Name

v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)

Synonyms

c-MAF; CCA4

Species

Homo sapiens

Ensembl Gene

ENSG00000178573

Encoded Proteins

IDBP-43182

v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)

IDBP-243811

v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)

IDBP-749048

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a DNA-binding, leucine zipper-containing transcription factor that acts as a homodimer or as a heterodimer. Depending on the binding site and binding partner, the encoded protein can be a transcriptional activator or repressor. This protein plays a role in the regulation of several cellular processes, including embryonic lens fiber cell development, increased T-cell susceptibility to apoptosis, and chondrocyte terminal differentiation. Defects in this gene are a cause of juvenile-onset pulverulent cataract as well as congenital cerulean cataract 4 (CCA4). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:79585843-79600714

Strand

Reverse strand

Band

q23.2

Transcripts

ENST00000326043	ENSP00000327048
ENST00000393350	ENSP00000377019
ENST00000569649	ENSP00000455097

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	32 [view]
Protein-Protein	26 [view]
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001816	cytokine production
GO:0002088	lens development in camera-type eye
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0010628	positive regulation of gene expression
GO:0032330	regulation of chondrocyte differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048468	cell development
GO:0048839	inner ear development
GO:0070306	lens fiber cell differentiation

Cellular Component

GO:0000785	chromatin
GO:0005634	nucleus
GO:0005737	cytoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000055435

View Gene Order

ENSBTAG00000044192

Not yet available

Pathways

NETPATH

REACTOME

KEGG

INOH

PID NCI

nfat_tfpathway

Calcineurin-regulated NFAT-dependent transcription in lymphocytes

ap1_pathway

AP-1 transcription factor network

cmyb_pathway

C-MYB transcription factor network

Cross-References

SwissProt

O75444

TrEMBL

UniProt Splice Variant

Entrez Gene

4094

UniGene

Hs.134859

RefSeq

NM_001031804 NM_005360

HUGO

HGNC:6776

OMIM

177075

CCDS

CCDS42198 CCDS10928

HPRD

01518

IMGT

EMBL

AC009159 AF055376 AF055377 AF055378 BC081542

GenPept

AAC27037 AAC27038 AAC27039 AAH81542

RNA Seq Atlas

4094