Homo sapiens Gene: CENPN
Summary
InnateDB Gene IDBG-43296.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CENPN
Gene Name centromere protein N
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000166451
Encoded Proteins
centromere protein N
centromere protein N
centromere protein N
centromere protein N
centromere protein N
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene forms part of the nucleosome-associated complex and is important for kinetochore assembly. It is bound to kinetochores during S phase and G2 and recruits other proteins to the centromere. Pseudogenes of this gene are located on chromosome 2. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:81006498-81033114
Strand Forward strand
Band q23.2
Transcripts
ENST00000305850 ENSP00000305608
ENST00000299572 ENSP00000299572
ENST00000393335 ENSP00000377007
ENST00000439957 ENSP00000395235
ENST00000428963 ENSP00000393991
ENST00000568445 ENSP00000454337
ENST00000562943 ENSP00000456413
ENST00000564669 ENSP00000454327
ENST00000569461
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated
Total 14 [view]
Protein-Protein 13 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0000278 mitotic cell cycle
GO:0006334 nucleosome assembly
GO:0007059 chromosome segregation
GO:0007067 mitotic nuclear division
GO:0034080 centromere-specific nucleosome assembly
GO:0034508 centromere complex assembly
Cellular Component
GO:0000775 chromosome, centromeric region
GO:0000777 condensed chromosome kinetochore
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Deposition of new CENPA-containing nucleosomes at the centromere pathway
Resolution of Sister Chromatid Cohesion pathway
Mitotic Prometaphase pathway
Separation of Sister Chromatids pathway
Chromosome Maintenance pathway
Nucleosome assembly pathway
Cell Cycle pathway
M Phase pathway
Mitotic Anaphase pathway
Cell Cycle, Mitotic pathway
Mitotic Metaphase and Anaphase pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q96H22
TrEMBL H3BMC7 H3BMD5
UniProt Splice Variant
Entrez Gene 55839
UniGene Hs.726537
RefSeq NM_001100624 NM_001100625 NM_001270473 NM_001270474 NM_018455 XM_006721236
HUGO HGNC:30873
OMIM 611509
CCDS CCDS10931 CCDS42199 CCDS42200 CCDS58482 CCDS58483
HPRD
IMGT
EMBL AC092718 AF217515 AK023669 AK026313 AK296024 AK298554 BC007334 BC008972 CH471114
GenPept AAF67626 AAH07334 AAH08972 BAG51215 BAG58793 BAG60749 EAW95553 EAW95556
RNA Seq Atlas 55839