Version 5.4
Homo sapiens Protein: CENPN
Summary
InnateDB Protein IDBP-43298.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CENPN
Protein Name centromere protein N
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000305608
InnateDB Gene IDBG-43296 (CENPN)
Protein Structure
UniProt Annotation
Function Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPN is the first protein to bind specifically to CENPA nucleosomes and the direct binding of CENPA nucleosomes by CENPN is required for centromere assembly. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate. {ECO:0000269PubMed:16622419, ECO:0000269PubMed:16716197, ECO:0000269PubMed:18007590, ECO:0000269PubMed:19543270}.
Subcellular Localization Nucleus. Chromosome, centromere, kinetochore. Note=Localizes exclusively in the kinetochore domain of centromeres. Kinetochore-bound levels decrease when cells enter mitosis and increase again when cells exit mitosis.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated
Total 14 [view]
Protein-Protein 13 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0000278 mitotic cell cycle
GO:0006334 nucleosome assembly
GO:0007059 chromosome segregation
GO:0007067 mitotic nuclear division
GO:0034080 centromere-specific nucleosome assembly
GO:0034508 centromere complex assembly
Cellular Component
GO:0000775 chromosome, centromeric region
GO:0000777 condensed chromosome kinetochore
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR007902 Centromere protein Chl4/mis15/CENP-N
PFAM PF05238
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96H22
PhosphoSite PhosphoSite-Q96H22
TrEMBL H3BMC7
UniProt Splice Variant
Entrez Gene 55839
UniGene Hs.726537
RefSeq NP_001094094
HUGO HGNC:30873
OMIM 611509
CCDS CCDS42200
HPRD 12528
IMGT
EMBL AC092718 AF217515 AK023669 AK026313 AK296024 AK298554 BC007334 BC008972 CH471114
GenPept AAF67626 AAH07334 AAH08972 BAG51215 BAG58793 BAG60749 EAW95553 EAW95556

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca