Version 5.4
Homo sapiens Gene: TFF1
Summary
InnateDB Gene IDBG-4330.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TFF1
Gene Name trefoil factor 1
Synonyms BCEI; D21S21; HP1.A; HPS2; pNR-2; pS2
Species Homo sapiens
Ensembl Gene ENSG00000160182
Encoded Proteins
IDBP-4332
trefoil factor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer, and affect healing of the epithelium. This gene, which is expressed in the gastric mucosa, has also been studied because of its expression in human tumors. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 21:42362282-42366594
Strand Reverse strand
Band q22.3
Transcripts
ENST00000291527 ENSP00000291527
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 48 experimentally validated interaction(s) in this database.
Experimentally validated
Total 48 [view]
Protein-Protein 14 [view]
Protein-DNA 31 [view]
Protein-RNA 0
DNA-DNA 3 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008083 growth factor activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0007586 digestion
GO:0008285 negative regulation of cell proliferation
GO:0010039 response to iron ion
GO:0030154 cell differentiation
GO:0030277 maintenance of gastrointestinal epithelium
GO:0032355 response to estradiol
GO:0035902 response to immobilization stress
GO:0043434 response to peptide hormone
Cellular Component
GO:0005615 extracellular space
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
era_genomic_pathway
Validated nuclear estrogen receptor alpha network
hnf3apathway
FOXA1 transcription factor network
Cross-References
SwissProt P04155
TrEMBL
UniProt Splice Variant
Entrez Gene 7031
UniGene
RefSeq NM_003225
HUGO HGNC:11755
OMIM 113710
CCDS CCDS13685
HPRD
IMGT
EMBL AB038162 AP001746 BC032811 M12075 X00474 X05030 X05321 X05322 X52003
GenPept AAA52402 AAH32811 BAA95532 BAB13729 CAA25155 CAA28695 CAA36254
RNA Seq Atlas 7031

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca