InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TFF1

Summary

InnateDB Protein

IDBP-4332.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TFF1

Protein Name

trefoil factor 1

Synonyms

BCEI; D21S21; HP1.A; HPS2; pNR-2; pS2;

Species

Homo sapiens

Ensembl Protein

ENSP00000291527

InnateDB Gene

IDBG-4330 (TFF1)

Protein Structure

UniProt Annotation

Function

Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents. May inhibit the growth of calcium oxalate crystals in urine. {ECO:0000269PubMed:16308573}.

Subcellular Localization

Secreted {ECO:0000269PubMed:15924415, ECO:0000269PubMed:3041593}.

Disease Associations

Tissue Specificity

Found in stomach, with highest levels in the upper gastric mucosal cells (at protein level). Detected in goblet cells of the small and large intestine and rectum, small submucosal glands in the esophagus, mucous acini of the sublingual gland, submucosal glands of the trachea, and epithelial cells lining the exocrine pancreatic ducts but not in the remainder of the pancreas (at protein level). Scattered expression is detected in the epithelial cells of the gallbladder and submucosal glands of the vagina, and weak expression is observed in the bronchial goblet cells of the pseudostratified epithelia in the respiratory system (at protein level). Detected in urine (at protein level). Strongly expressed in breast cancer but at low levels in normal mammary tissue. It is regulated by estrogen in MCF-7 cells. Strong expression found in normal gastric mucosa and in the regenerative tissues surrounding ulcerous lesions of gastrointestinal tract, but lower expression found in gastric cancer (at protein level). {ECO:0000269PubMed:15924415, ECO:0000269PubMed:16308573, ECO:0000269PubMed:16718800, ECO:0000269PubMed:17143957, ECO:0000269PubMed:17242463, ECO:0000269PubMed:3041593, ECO:0000269PubMed:3838275}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 48 experimentally validated interaction(s) in this database.

Experimentally validated
Total	48 [view]
Protein-Protein	14 [view]
Protein-DNA	31 [view]
Protein-RNA	0
DNA-DNA	3 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008083	growth factor activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0007586	digestion
GO:0008285	negative regulation of cell proliferation
GO:0010039	response to iron ion
GO:0030154	cell differentiation
GO:0030277	maintenance of gastrointestinal epithelium
GO:0032355	response to estradiol
GO:0035902	response to immobilization stress
GO:0043434	response to peptide hormone