Version 5.4
Homo sapiens Gene: HPN
Summary
InnateDB Gene IDBG-43408.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HPN
Gene Name hepsin
Synonyms TMPRSS1
Species Homo sapiens
Ensembl Gene ENSG00000105707
Encoded Proteins
IDBP-43410
hepsin
IDBP-246090
hepsin
IDBP-763850
IDBP-763003
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a type II transmembrane serine protease that may be involved in diverse cellular functions, including blood coagulation and the maintenance of cell morphology. Expression of the encoded protein is associated with the growth and progression of cancers, particularly prostate cancer. The protein is cleaved into a catalytic serine protease chain and a non-catalytic scavenger receptor cysteine-rich chain, which associate via a single disulfide bond. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:35040506-35066571
Strand Forward strand
Band q13.11
Transcripts
ENST00000262626 ENSP00000262626
ENST00000392226 ENSP00000376060
ENST00000541345
ENST00000597419 ENSP00000470327
ENST00000600390 ENSP00000472310
ENST00000593305
ENST00000600675
ENST00000596662
ENST00000599363
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008236 serine-type peptidase activity
GO:0015269 calcium-activated potassium channel activity
GO:0070008 serine-type exopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0007605 sensory perception of sound
GO:0008360 regulation of cell shape
GO:0010628 positive regulation of gene expression
GO:0010693 negative regulation of alkaline phosphatase activity
GO:0010719 negative regulation of epithelial to mesenchymal transition
GO:0010756 positive regulation of plasminogen activation
GO:0030307 positive regulation of cell growth
GO:0034769 basement membrane disassembly
GO:0042632 cholesterol homeostasis
GO:0043066 negative regulation of apoptotic process
GO:0043923 positive regulation by host of viral transcription
GO:0050680 negative regulation of epithelial cell proliferation
GO:0050910 detection of mechanical stimulus involved in sensory perception of sound
GO:0060429 epithelium development
GO:0071805 potassium ion transmembrane transport
GO:0090103 cochlea morphogenesis
GO:0097066 response to thyroid hormone
GO:0097195 pilomotor reflex
GO:2000347 positive regulation of hepatocyte proliferation
GO:2000611 positive regulation of thyroid hormone generation
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005911 cell-cell junction
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031965 nuclear membrane
GO:0043025 neuronal cell body
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000001249
View Gene Order
ENSBTAG00000003829
Not yet available
Cross-References
SwissProt
TrEMBL M0QZ63
UniProt Splice Variant
Entrez Gene 3249
UniGene
RefSeq NM_002151 NM_182983 XM_006723181
HUGO HGNC:5155
OMIM 142440
CCDS CCDS32993
HPRD 00801
IMGT
EMBL AC020907
GenPept
RNA Seq Atlas 3249

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca