InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HPN

Summary

InnateDB Protein

IDBP-43410.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HPN

Protein Name

hepsin

Synonyms

TMPRSS1;

Species

Homo sapiens

Ensembl Protein

ENSP00000262626

InnateDB Gene

IDBG-43408 (HPN)

Protein Structure

UniProt Annotation

Function

Plays an essential role in cell growth and maintenance of cell morphology. May mediate the activating cleavage of HGF and MST1/HGFL. Plays a role in the proteolytic processing of ACE2. {ECO:0000269PubMed:15839837, ECO:0000269PubMed:21875933, ECO:0000269PubMed:24227843}.

Subcellular Localization

Membrane; Single-pass type II membrane protein.

Disease Associations

Tissue Specificity

Present in most tissues, with the highest level in liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0008236	serine-type peptidase activity
GO:0015269	calcium-activated potassium channel activity
GO:0070008	serine-type exopeptidase activity

Biological Process

GO:0006508	proteolysis
GO:0007605	sensory perception of sound
GO:0008360	regulation of cell shape
GO:0010628	positive regulation of gene expression
GO:0010693	negative regulation of alkaline phosphatase activity
GO:0010719	negative regulation of epithelial to mesenchymal transition
GO:0010756	positive regulation of plasminogen activation
GO:0030307	positive regulation of cell growth
GO:0034769	basement membrane disassembly
GO:0042632	cholesterol homeostasis
GO:0043066	negative regulation of apoptotic process
GO:0043923	positive regulation by host of viral transcription
GO:0050680	negative regulation of epithelial cell proliferation
GO:0050910	detection of mechanical stimulus involved in sensory perception of sound
GO:0060429	epithelium development
GO:0071805	potassium ion transmembrane transport
GO:0090103	cochlea morphogenesis
GO:0097066	response to thyroid hormone
GO:0097195	pilomotor reflex
GO:2000347	positive regulation of hepatocyte proliferation
GO:2000611	positive regulation of thyroid hormone generation

Cellular Component

GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005911	cell-cell junction
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031965	nuclear membrane
GO:0043025	neuronal cell body
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR009003 Trypsin-like cysteine/serine peptidase domain
IPR015352 Hepsin, SRCR domain
IPR017448 SRCR-like domain

PFAM

PF00089
PF09272

PRINTS

PR00722

PIRSF

SMART

SM00020
SM00202

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt