Version 5.4
Homo sapiens Gene: SUCLG2
Summary
InnateDB Gene IDBG-43703.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SUCLG2
Gene Name succinate-CoA ligase, GDP-forming, beta subunit
Synonyms GBETA
Species Homo sapiens
Ensembl Gene ENSG00000172340
Encoded Proteins
IDBP-43705
succinate-CoA ligase, GDP-forming, beta subunit
IDBP-484031
succinate-CoA ligase, GDP-forming, beta subunit
IDBP-476148
succinate-CoA ligase, GDP-forming, beta subunit
IDBP-475464
succinate-CoA ligase, GDP-forming, beta subunit
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a GTP-specific beta subunit of succinyl-CoA synthetase. Succinyl-CoA synthetase catalyzes the reversible reaction involving the formation of succinyl-CoA and succinate. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 5 and 12. [provided by RefSeq, Apr 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:67360460-67654614
Strand Reverse strand
Band p14.1
Transcripts
ENST00000307227 ENSP00000307432
ENST00000493112 ENSP00000419325
ENST00000460567 ENSP00000417260
ENST00000492795 ENSP00000417589
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
Experimentally validated
Total 23 [view]
Protein-Protein 23 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004776 succinate-CoA ligase (GDP-forming) activity
GO:0005524 ATP binding
GO:0005525 GTP binding
GO:0019003 GDP binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006099 tricarboxylic acid cycle
GO:0006104 succinyl-CoA metabolic process
GO:0006105 succinate metabolic process
GO:0008152 metabolic process
GO:0044237 cellular metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005886 plasma membrane
GO:0043234 protein complex
GO:0045244 succinate-CoA ligase complex (GDP-forming)
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000061838
View Gene Order
ENSBTAG00000009541
Not yet available
Pathways
NETPATH
REACTOME
REACT_1785
Citric acid cycle (TCA cycle) pathway
REACT_1046
Pyruvate metabolism and Citric Acid (TCA) cycle pathway
REACT_111083
The citric acid (TCA) cycle and respiratory electron transport pathway
REACT_111217
Metabolism pathway
KEGG
hsa00020
Citrate cycle (TCA cycle) pathway
hsa00640
Propanoate metabolism pathway
INOH
INOH website
Citrate cycle pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.644919 Hs.723448
RefSeq NM_001177599 NM_003848 XM_005264773
HUGO
OMIM
CCDS CCDS43104 CCDS54605
HPRD 06799
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca