InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SUCLG2

Summary

InnateDB Protein

IDBP-484031.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SUCLG2

Protein Name

succinate-CoA ligase, GDP-forming, beta subunit

Synonyms

GBETA;

Species

Homo sapiens

Ensembl Protein

ENSP00000419325

InnateDB Gene

IDBG-43703 (SUCLG2)

Protein Structure

UniProt Annotation

Function

Catalyzes the GTP-dependent ligation of succinate and CoA to form succinyl-CoA. {ECO:0000250}.

Subcellular Localization

Mitochondrion.

Disease Associations

Tissue Specificity

Mainly expressed in liver, kidney, heart, spleen and skeletal muscle. Also found in intestine and colon, and in low amounts in lung, brain, prostate, testis and ovary. {ECO:0000269PubMed:9765291}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.

Experimentally validated
Total	23 [view]
Protein-Protein	23 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004776	succinate-CoA ligase (GDP-forming) activity
GO:0005524	ATP binding
GO:0005525	GTP binding
GO:0019003	GDP binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006099	tricarboxylic acid cycle
GO:0006104	succinyl-CoA metabolic process
GO:0006105	succinate metabolic process
GO:0008152	metabolic process
GO:0044237	cellular metabolic process
GO:0044281	small molecule metabolic process

Cellular Component

GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix
GO:0005886	plasma membrane
GO:0043234	protein complex
GO:0045244	succinate-CoA ligase complex (GDP-forming)

Protein Structure and Domains

PDB ID

InterPro

IPR005809 Succinyl-CoA synthetase, beta subunit
IPR005811 ATP-citrate lyase/succinyl-CoA ligase
IPR013650 ATP-grasp fold, succinyl-CoA synthetase-type
IPR016102 Succinyl-CoA synthetase-like

PFAM

PF00549
PF08442

PRINTS

PIRSF

PIRSF001554

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q96I99