Version 5.4
Homo sapiens Gene: HIPK2
Summary
InnateDB Gene IDBG-43737.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HIPK2
Gene Name homeodomain interacting protein kinase 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000064393
Encoded Proteins
IDBP-43741
homeodomain interacting protein kinase 2
IDBP-294130
homeodomain interacting protein kinase 2
IDBP-386790
homeodomain interacting protein kinase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a conserved serine/threonine kinase that is a member of the homeodomain-interacting protein kinase family. The encoded protein interacts with homeodomain transcription factors and many other transcription factors such as p53, and can function as both a corepressor and a coactivator depending on the transcription factor and its subcellular localization. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:139561570-139777778
Strand Reverse strand
Band q34
Transcripts
ENST00000342645 ENSP00000343108
ENST00000406875 ENSP00000385571
ENST00000428878 ENSP00000413724
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 106 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 106 [view]
Protein-Protein 104 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001102 RNA polymerase II activating transcription factor binding
GO:0001105 RNA polymerase II transcription coactivator activity
GO:0003714 transcription corepressor activity
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0046332 SMAD binding
GO:0046790 virion binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001654 eye development
GO:0001934 positive regulation of protein phosphorylation
GO:0006351 transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007224 smoothened signaling pathway
GO:0007628 adult walking behavior
GO:0008284 positive regulation of cell proliferation
GO:0008344 adult locomotory behavior
GO:0009103 lipopolysaccharide biosynthetic process
GO:0009952 anterior/posterior pattern specification
GO:0010842 retina layer formation
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0019048 modulation by virus of host morphology or physiology
GO:0030182 neuron differentiation
GO:0030218 erythrocyte differentiation
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
GO:0030514 negative regulation of BMP signaling pathway
GO:0030578 PML body organization
GO:0032092 positive regulation of protein binding
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043388 positive regulation of DNA binding
GO:0043524 negative regulation of neuron apoptotic process
GO:0045766 positive regulation of angiogenesis
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046330 positive regulation of JNK cascade
GO:0048596 embryonic camera-type eye morphogenesis
GO:0050882 voluntary musculoskeletal movement
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051726 regulation of cell cycle
GO:0060059 embryonic retina morphogenesis in camera-type eye
GO:0060235 lens induction in camera-type eye
GO:0060395 SMAD protein signal transduction
GO:0061072 iris morphogenesis
GO:0071456 cellular response to hypoxia
GO:0097193 intrinsic apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0016604 nuclear body
GO:0016605 PML body
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000061436
View Gene Order
ENSBTAG00000017860
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
REACT_118713
YAP1- and WWTR1 (TAZ)-stimulated gene expression pathway
REACT_12627
Generic Transcription Pathway pathway
REACT_71
Gene Expression pathway
KEGG
INOH
PID NCI
p53regulationpathway
p53 pathway
cmyb_pathway
C-MYB transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.593999 Hs.596738 Hs.610128 Hs.623235 Hs.623909 Hs.731417
RefSeq NM_001113239 NM_022740 XM_006715934 XM_006715935
HUGO
OMIM
CCDS CCDS75666 CCDS75667
HPRD 06039
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca