InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.24840

Summary

InnateDB Gene

IDBG-636182.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.24840

Gene Name

homeodomain-interacting protein kinase 2

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000017860

Encoded Proteins

IDBP-688125

homeodomain interacting protein kinase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000064393:
This gene encodes a conserved serine/threonine kinase that is a member of the homeodomain-interacting protein kinase family. The encoded protein interacts with homeodomain transcription factors and many other transcription factors such as p53, and can function as both a corepressor and a coactivator depending on the transcription factor and its subcellular localization. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:103888216-104017538

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000023740

ENSBTAP00000023740

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 48 interaction(s) predicted by orthology.

Predicted by orthology
Total	48 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0001102	RNA polymerase II activating transcription factor binding
GO:0001105	RNA polymerase II transcription coactivator activity
GO:0003714	transcription corepressor activity
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016773	phosphotransferase activity, alcohol group as acceptor
GO:0046332	SMAD binding
GO:0046790	virion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001934	positive regulation of protein phosphorylation
GO:0006468	protein phosphorylation
GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007224	smoothened signaling pathway
GO:0007628	adult walking behavior
GO:0008284	positive regulation of cell proliferation
GO:0008344	adult locomotory behavior
GO:0009103	lipopolysaccharide biosynthetic process
GO:0009952	anterior/posterior pattern specification
GO:0010842	retina layer formation
GO:0018105	peptidyl-serine phosphorylation
GO:0018107	peptidyl-threonine phosphorylation
GO:0030182	neuron differentiation
GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway
GO:0030514	negative regulation of BMP signaling pathway
GO:0032092	positive regulation of protein binding
GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043388	positive regulation of DNA binding
GO:0043524	negative regulation of neuron apoptotic process
GO:0045766	positive regulation of angiogenesis
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046330	positive regulation of JNK cascade
GO:0048596	embryonic camera-type eye morphogenesis
GO:0050882	voluntary musculoskeletal movement
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060059	embryonic retina morphogenesis in camera-type eye
GO:0060235	lens induction in camera-type eye
GO:0060395	SMAD protein signal transduction
GO:0061072	iris morphogenesis