Version 5.4
Homo sapiens Gene: AFF4
Summary
InnateDB Gene IDBG-43817.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AFF4
Gene Name AF4/FMR2 family, member 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000072364
Encoded Proteins
IDBP-43821
AF4/FMR2 family, member 4
IDBP-43823
AF4/FMR2 family, member 4
IDBP-376709
AF4/FMR2 family, member 4
IDBP-376713
AF4/FMR2 family, member 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the AF4 family of transcription factors involved in leukemia. It is a component of the positive transcription elongation factor b (P-TEFb) complex. A chromosomal translocation involving this gene and MLL gene on chromosome 11 is found in infant acute lymphoblastic leukemia with ins(5;11)(q31;q31q23). [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:132875379-132963634
Strand Reverse strand
Band q31.1
Transcripts
ENST00000265343 ENSP00000265343
ENST00000378595 ENSP00000367858
ENST00000378593
ENST00000425658 ENSP00000409069
ENST00000421773 ENSP00000395268
ENST00000478588
ENST00000477369
ENST00000491831
ENST00000465484
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 30 [view]
Protein-Protein 28 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0007286 spermatid development
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005739 mitochondrion
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000049470
View Gene Order
ENSBTAG00000009482
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.519313 Hs.598930 Hs.604187
RefSeq NM_014423 XM_005271963 XM_005271964
HUGO
OMIM
CCDS CCDS4164
HPRD 09187
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca