Version 5.4
Bos taurus Gene: AFF4
Summary
InnateDB Gene IDBG-645722.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AFF4
Gene Name AF4/FMR2 family member 4
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000009482
Encoded Proteins
IDBP-698466
AF4/FMR2 family, member 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000072364:
The protein encoded by this gene belongs to the AF4 family of transcription factors involved in leukemia. It is a component of the positive transcription elongation factor b (P-TEFb) complex. A chromosomal translocation involving this gene and MLL gene on chromosome 11 is found in infant acute lymphoblastic leukemia with ins(5;11)(q31;q31q23). [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:46082730-46161887
Strand Reverse strand
Band
Transcripts
ENSBTAT00000012480 ENSBTAP00000012480
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.
Predicted by orthology
Total 30 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007286 spermatid development
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005739 mitochondrion
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000072364
View Gene Order
ENSMUSG00000049470
View Gene Order
Cross-References
SwissProt
TrEMBL E1BCF6
UniProt Splice Variant
Entrez Gene 541306
UniGene Bt.38060
RefSeq NM_001191129 XM_005209304 XM_005209305
HUGO HGNC:17869
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02020296
GenPept
RNA Seq Atlas 541306

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca