Version 5.4
Homo sapiens Gene: TSFM
Summary
InnateDB Gene IDBG-43934.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TSFM
Gene Name Ts translation elongation factor, mitochondrial
Synonyms EFTS; EFTSMT
Species Homo sapiens
Ensembl Gene ENSG00000123297
Encoded Proteins
IDBP-43936
Ts translation elongation factor, mitochondrial
IDBP-379173
Ts translation elongation factor, mitochondrial
IDBP-379175
Ts translation elongation factor, mitochondrial
IDBP-379178
Ts translation elongation factor, mitochondrial
IDBP-379181
Ts translation elongation factor, mitochondrial
IDBP-592156
Ts translation elongation factor, mitochondrial
IDBP-604050
Ts translation elongation factor, mitochondrial
IDBP-601967
Ts translation elongation factor, mitochondrial
IDBP-603127
Ts translation elongation factor, mitochondrial
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a mitochondrial translation elongation factor. The encoded protein is an enzyme that catalyzes the exchange of guanine nucleotides on the translation elongation factor Tu during the elongation step of mitchondrial protein translation. Mutations in this gene are associated with combined oxidative phosphorylation deficiency-3 syndrome. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:57782589-57808071
Strand Forward strand
Band q14.1
Transcripts
ENST00000323833 ENSP00000313877
ENST00000454289 ENSP00000388330
ENST00000417094 ENSP00000406339
ENST00000434359 ENSP00000390679
ENST00000457189 ENSP00000389162
ENST00000497617
ENST00000550559 ENSP00000448575
ENST00000548851 ENSP00000450041
ENST00000543727 ENSP00000439342
ENST00000540550 ENSP00000440987
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003746 translation elongation factor activity
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006414 translational elongation
GO:0032784 regulation of DNA-templated transcription, elongation
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005739 mitochondrion
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000040521
View Gene Order
ENSBTAG00000016912
Not yet available
Pathways
NETPATH
REACTOME
REACT_200751
Organelle biogenesis and maintenance pathway
REACT_267673
Mitochondrial translation pathway
REACT_267677
Mitochondrial translation elongation pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt P43897
TrEMBL
UniProt Splice Variant
Entrez Gene 10102
UniGene
RefSeq NM_001172696 NM_001172695 NM_001172697 NM_005726
HUGO HGNC:12367
OMIM 604723
CCDS CCDS53809 CCDS53810 CCDS53811 CCDS8958
HPRD 05285
IMGT
EMBL AC025165 AF110399 AK304621 AK308981 BC022862 BC093068 CH471054 L37936
GenPept AAC37577 AAD20224 AAH22862 AAH93068 BAG65403 EAW97075
RNA Seq Atlas 10102

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca