InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TSFM

Summary

InnateDB Protein

IDBP-43936.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TSFM

Protein Name

Ts translation elongation factor, mitochondrial

Synonyms

EFTS; EFTSMT;

Species

Homo sapiens

Ensembl Protein

ENSP00000313877

InnateDB Gene

IDBG-43934 (TSFM)

Protein Structure

UniProt Annotation

Function

Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. {ECO:0000255HAMAP-Rule:MF_03135}.

Subcellular Localization

Mitochondrion.

Disease Associations

Combined oxidative phosphorylation deficiency 3 (COXPD3) [MIM:610505]: A mitochondrial disease resulting in severe metabolic acidosis with encephalomyopathy or with hypertrophic cardiomyopathy. Patients show a severe defect in mitochondrial translation leading to a failure to assemble adequate amounts of three of the oxidative phosphorylation complexes. {ECO:0000269PubMed:17033963, ECO:0000269PubMed:22499341}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed in all tissues, with the highest levels of expression in skeletal muscle, liver and kidney.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003746	translation elongation factor activity
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006414	translational elongation
GO:0032784	regulation of DNA-templated transcription, elongation

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005739	mitochondrion

Protein Structure and Domains

PDB ID

InterPro

IPR000449 Ubiquitin-associated domain/translation elongation factor EF-Ts, N-terminal
IPR009060 UBA-like
IPR014039 Translation elongation factor EFTs/EF1B, dimerisation

PFAM

PF00627
PF00889

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P43897

PhosphoSite