Homo sapiens Gene: RASGRP3 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Gene | IDBG-43993.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | RASGRP3 | ||||||||||||||||||
Gene Name | RAS guanyl releasing protein 3 (calcium and DAG-regulated) | ||||||||||||||||||
Synonyms | GRP3 | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Gene | ENSG00000152689 | ||||||||||||||||||
Encoded Proteins |
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
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Protein Structure | |||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
Entrez Gene | |||||||||||||||||||
Summary |
Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RASGRP3, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008] |
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Gene Information | |||||||||||||||||||
Type | Protein coding | ||||||||||||||||||
Genomic Location | Chromosome 2:33436324-33564750 | ||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||
Band | p22.3 | ||||||||||||||||||
Transcripts | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||
NETPATH |
BCR pathway
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REACTOME |
Activation of RAS in B cells pathway
Adaptive Immune System pathway
Immune System pathway
Signaling by the B Cell Receptor (BCR) pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
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KEGG |
MAPK signaling pathway pathway
B cell receptor signaling pathway pathway
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INOH | |||||||||||||||||||
PID NCI |
Regulation of Ras family activation
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Cross-References | |||||||||||||||||||
SwissProt | |||||||||||||||||||
TrEMBL | |||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | |||||||||||||||||||
UniGene | Hs.143674 Hs.603716 | ||||||||||||||||||
RefSeq | NM_001139488 NM_015376 NM_170672 XM_005264246 XM_005264247 | ||||||||||||||||||
HUGO | |||||||||||||||||||
OMIM | |||||||||||||||||||
CCDS | CCDS46256 CCDS54346 | ||||||||||||||||||
HPRD | 15213 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | |||||||||||||||||||
GenPept | |||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||