Bos taurus Gene: RASGRP3 | |||||||||||||||||
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Summary | |||||||||||||||||
InnateDB Gene | IDBG-632283.3 | ||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||
Gene Symbol | RASGRP3 | ||||||||||||||||
Gene Name | ras guanyl-releasing protein 3 | ||||||||||||||||
Synonyms | |||||||||||||||||
Species | Bos taurus | ||||||||||||||||
Ensembl Gene | ENSBTAG00000008006 | ||||||||||||||||
Encoded Proteins |
ras guanyl-releasing protein 3
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Protein Structure | |||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||
Entrez Gene | |||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000152689:
Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RASGRP3, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008] |
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Gene Information | |||||||||||||||||
Type | Protein coding | ||||||||||||||||
Genomic Location | Chromosome 11:16087064-16134216 | ||||||||||||||||
Strand | Forward strand | ||||||||||||||||
Band | |||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathway Predictions based on Human Orthology Data | |||||||||||||||||
NETPATH |
BCR pathway
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REACTOME |
Activation of RAS in B cells pathway
Adaptive Immune System pathway
Immune System pathway
Signaling by the B Cell Receptor (BCR) pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
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KEGG |
MAPK signaling pathway pathway
B cell receptor signaling pathway pathway
MAPK signaling pathway pathway
B cell receptor signaling pathway pathway
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INOH | |||||||||||||||||
PID NCI |
Regulation of Ras family activation
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Cross-References | |||||||||||||||||
SwissProt | |||||||||||||||||
TrEMBL | Q0VD52 | ||||||||||||||||
UniProt Splice Variant | |||||||||||||||||
Entrez Gene | 523745 | ||||||||||||||||
UniGene | Bt.61807 | ||||||||||||||||
RefSeq | NM_001075848 XM_005212531 XM_005212532 XM_005212533 XM_005212534 | ||||||||||||||||
HUGO | |||||||||||||||||
OMIM | |||||||||||||||||
CCDS | |||||||||||||||||
HPRD | |||||||||||||||||
IMGT | |||||||||||||||||
EMBL | BC119832 DAAA02030471 | ||||||||||||||||
GenPept | AAI19833 | ||||||||||||||||
RNA Seq Atlas | 523745 | ||||||||||||||||