InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GABRA5

Summary

InnateDB Gene

IDBG-4400.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GABRA5

Gene Name

gamma-aminobutyric acid (GABA) A receptor, alpha 5

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000186297

Encoded Proteins

IDBP-4402

gamma-aminobutyric acid (GABA) A receptor, alpha 5

IDBP-4404

gamma-aminobutyric acid (GABA) A receptor, alpha 5

IDBP-229073

gamma-aminobutyric acid (GABA) A receptor, alpha 5

IDBP-593192

gamma-aminobutyric acid (GABA) A receptor, alpha 5

IDBP-598897

gamma-aminobutyric acid (GABA) A receptor, alpha 5

IDBP-592557

gamma-aminobutyric acid (GABA) A receptor, alpha 5

IDBP-599528

gamma-aminobutyric acid (GABA) A receptor, alpha 5

IDBP-595578

gamma-aminobutyric acid (GABA) A receptor, alpha 5

IDBP-593881

gamma-aminobutyric acid (GABA) A receptor, alpha 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Transcript variants utilizing three different alternative non-coding first exons have been described. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:26866363-26949207

Strand

Forward strand

Band

q12

Transcripts

ENST00000335625	ENSP00000335592
ENST00000355395	ENSP00000347557
ENST00000400081	ENSP00000382953
ENST00000555182	ENSP00000450653
ENST00000557484
ENST00000554038	ENSP00000451527
ENST00000554596	ENSP00000450806
ENST00000557449
ENST00000555060	ENSP00000450932
ENST00000554599	ENSP00000450717
ENST00000554083	ENSP00000450529

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0004890	GABA-A receptor activity
GO:0005215	transporter activity
GO:0005230	extracellular ligand-gated ion channel activity
GO:0005254	chloride channel activity
GO:0005515	protein binding
GO:0050811	GABA receptor binding

Biological Process

GO:0001662	behavioral fear response
GO:0006810	transport
GO:0006811	ion transport
GO:0006821	chloride transport
GO:0007165	signal transduction
GO:0007214	gamma-aminobutyric acid signaling pathway
GO:0007268	synaptic transmission
GO:0007420	brain development
GO:0007605	sensory perception of sound
GO:0008306	associative learning
GO:0034220	ion transmembrane transport
GO:0043523	regulation of neuron apoptotic process
GO:0043524	negative regulation of neuron apoptotic process
GO:0048666	neuron development
GO:0055085	transmembrane transport
GO:0060119	inner ear receptor cell development
GO:0060384	innervation
GO:0090102	cochlea development
GO:1902476	chloride transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0030425	dendrite
GO:0032809	neuronal cell body membrane
GO:0034707	chloride channel complex
GO:0043235	receptor complex
GO:0044297	cell body
GO:0045211	postsynaptic membrane